Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Alzheimer's disease and its treatment by different approaches: A review

S Srivastava, R Ahmad, SK Khare - European Journal of Medicinal …, 2021 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that impairs mental ability
development and interrupts neurocognitive function. This neuropathological condition is …

The pivotal role of NF-kB in the pathogenesis and therapeutics of Alzheimer's disease

E Sun, A Motolani, L Campos, T Lu - International journal of molecular …, 2022 - mdpi.com
Alzheimer's Disease (AD) is the most common neurodegenerative disease worldwide, with a
high prevalence that is expected to double every 20 years. Besides the formation of Aβ …

The biological pathways of Alzheimer disease: A review

M Calabrò, C Rinaldi, G Santoro… - AIMS …, 2020 - pmc.ncbi.nlm.nih.gov
Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older
people, which severely impairs patients' quality of life. In the recent years, the number of …

Microglia in Alzheimer disease: well-known targets and new opportunities

AL Hemonnot, J Hua, L Ulmann… - Frontiers in aging …, 2019 - frontiersin.org
Microglia are the resident macrophages of the central nervous system. They play key roles
in brain development, and physiology during life and aging. Equipped with a variety of …

Role of Microglia and Astrocytes in Alzheimer's Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

G Di Benedetto, C Burgaletto, CM Bellanca, A Munafò… - Cells, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia worldwide, with a complex,
poorly understood pathogenesis. Cerebral atrophy, amyloid-β (Aβ) plaques, and …

[HTML][HTML] Alzheimer disease

A Kumar, J Sidhu, A Goyal, JW Tsao - 2018 - europepmc.org
Objectives: Identify the risk factors associated with Alzheimer disease. Describe the atypical
presentations of Alzheimer disease. Summarize and differentiate between the preclinical …

Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease

JS Bhatti, S Kaur, J Mishra, H Dibbanti, A Singh… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease that manifests its pathology
through synaptic damage, mitochondrial abnormalities, microRNA deregulation, hormonal …

Dysfunctional glucose metabolism in Alzheimer's disease onset and potential pharmacological interventions

V Kumar, SH Kim, K Bishayee - International Journal of Molecular …, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common age-related dementia. The alteration in
metabolic characteristics determines the prognosis. Patients at risk show reduced glucose …

Lipid and lipid raft alteration in aging and neurodegenerative diseases: a window for the development of new biomarkers

F Mesa-Herrera, L Taoro-González… - International journal of …, 2019 - mdpi.com
Lipids in the brain are major components playing structural functions as well as
physiological roles in nerve cells, such as neural communication, neurogenesis, synaptic …