Sudden unexpected death in epilepsy (SUDEP) can affect individuals of any age, but is most
common in younger adults (aged 20–45 years). Generalised tonic-clonic seizures are the …

SCN1A, encoding the alpha 1 subunit of the sodium channel, is associated with several
epilepsy syndromes and a range of other diseases. SCN1A represents the archetypal …

Although sudden cardiac death (SCD) is one of the most important modes of death in
Western countries, pathologists and public health physicians have not given this problem …

Forty per cent (40%) of sudden unexpected natural deaths in people under 35 years of age
are associated with a negative autopsy, and the cardiac ion channelopathies are the prime …

Introduction Premature mortality is a major issue in Dravet syndrome (DS). To improve
understanding of DS premature mortality, we conducted a comprehensive literature search …

Background Sudden unexpected death in epilepsy (SUDEP) is the leading cause of
epilepsy‐related death. SUDEP shares many features with sudden cardiac death and …

The influence of the central nervous system and autonomic system on cardiac activity is
being intensively studied, as it contributes to the high rate of cardiologic comorbidities …

Influx of sodium ions through voltage-gated sodium channels in cardiomyocytes is essential
for proper electrical conduction within the heart. Both acquired conditions associated with …

This review aims to empower general neurologists to provide better informed person‐
centred advice on sudden unexpected death in epilepsy (SUDEP) to people with epilepsy in …

The risk of dying suddenly and unexpectedly is increased 24‐to 28‐fold among young
people with epilepsy compared to the general population, but the incidence of sudden …