Background: The amyloidoses are a rare and heterogeneous group of disorders that are
characterized by the deposition of abnormally folded proteins in tissues ultimately leading to …

Often considered a rare disease, cardiac amyloidosis is increasingly recognized by
practicing clinicians. The increased rate of diagnosis is in part due the aging of the …

In amyloid light-chain (AL) amyloidosis, small B-cell clones (mostly plasma cell clones)
present in the bone marrow proliferate and secrete unstable monoclonal free light chains …

Light chain amyloidosis (AL) is a systemic disease in which abnormally proliferating plasma
cells secrete large amounts of mutated antibody light chains (LCs) that eventually form …

Since the mid-nineteenth century pathology has followed the convoluted story of
amyloidosis, recognized its morphology in tissues and made identification possible using …

Amyloidoses is a group of diseases characterized by the accumulation of abnormal proteins
(called amyloids) in different organs and tissues. For systemic amyloidoses, the disease is …

The deposition of amyloid light chains (LCs) in target sites translates into tissue damage and
organ dysfunction. Clinical and experimental advances have cast new light on the …

Purpose of Review: This review summarizes the current evidence for the involvement of
proteotoxicity and protein quality control systems defects in diseases of the central nervous …

Systemic antibody light chain (AL) amyloidosis is characterized by deposition of amyloid
fibrils. Prior to fibril formation, soluble oligomeric AL protein has a direct cytotoxic effect on …

Systemic light-chain (AL) amyloidosis is a monoclonal plasma cell disease characterized by
the deposition of amyloidogenic monoclonal light-chain fragments in organs, causing their …