International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function

NM Barnes, GP Ahern, C Becamel, J Bockaert… - Pharmacological …, 2021 - Elsevier
HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?

BP Guiard, GD Giovanni - Frontiers in Pharmacology, 2015 - frontiersin.org
5-Hydroxytryptamine 2A receptors (5-HT2A-Rs) are G-protein coupled receptors. In
agreement with their location in the brain, they have been implicated not only in various …

The ketogenic diet and neuroinflammation: the action of beta-hydroxybutyrate in a microglial cell line

R Polito, ME La Torre, F Moscatelli, G Cibelli… - International Journal of …, 2023 - mdpi.com
The ketogenic diet (KD), a diet high in fat and protein but low in carbohydrates, is gaining
much interest due to its positive effects, especially in neurodegenerative diseases. Beta …

New therapeutic opportunities for 5-HT2C receptor ligands in neuropsychiatric disorders

G Di Giovanni, P De Deurwaerdère - Pharmacology & therapeutics, 2016 - Elsevier
Abstract The 5-HT 2C receptor (R) displays a widespread distribution in the CNS and is
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …

[HTML][HTML] Smart drugs and neuroenhancement: what do we know?

M Esposito, G Cocimano, F Ministrieri… - Frontiers in Bioscience …, 2021 - imrpress.com
Introduction: Smart drugs are among the most common drugs used by students. It is
estimated that they are second in incidence after cannabis. Although they are usually used …

Constitutive activity of 5-HT receptors: Factual analysis

P De Deurwaerdère, R Bharatiya, A Chagraoui… - …, 2020 - Elsevier
The constitutive activity of different serotonin receptors (5-HTRs) toward intracellular
signaling pathways has been proposed to have physiological and pathological importance …

Pharmacogenetics and forensic toxicology: A new step towards a multidisciplinary approach

N Di Nunno, M Esposito, A Argo, M Salerno, F Sessa - Toxics, 2021 - mdpi.com
Pharmacogenetics analyzes the individual behavior of DNA genes after the administration of
a drug. Pharmacogenetic research has been implemented in recent years thanks to the …

Monoaminergic mechanisms in epilepsy may offer innovative therapeutic opportunity for monoaminergic multi-target drugs

D Svob Strac, N Pivac, IJ Smolders, WA Fogel… - Frontiers in …, 2016 - frontiersin.org
A large body of experimental and clinical evidence has strongly suggested that monoamines
play an important role in regulating epileptogenesis, seizure susceptibility, convulsions, and …

Advances in technologies in crime scene investigation

M Esposito, F Sessa, G Cocimano, P Zuccarello… - Diagnostics, 2023 - mdpi.com
Crime scene investigation (CSI) is the complex act of reconstructing the dynamics that led to
a crime and the circumstances of its perpetration. Crystallizing the CSI is a difficult task for …

Neurobiology and medico-legal aspects of suicides among older adults: a narrative review

F Sessa, R Polito, G Li Rosi, M Salerno… - Frontiers in …, 2024 - frontiersin.org
The task of preventing suicide in older adults is an important social burden as older adults
aged above 65 are exposed to singular psychological aspects that increase suicide risks …