Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …

The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …

Emerging spatial technologies, including spatial transcriptomics and spatial epigenomics,
are becoming powerful tools for profiling of cellular states in the tissue context,,,–. However …

In this study, we extended co-indexing of transcriptomes and epitopes (CITE) to the spatial
dimension and demonstrated high-plex protein and whole transcriptome co-mapping. We …

Defining the transition from benign to malignant tissue is fundamental to improving early
diagnosis of cancer. Here we use a systematic approach to study spatial genome integrity in …

Although complex inflammatory-like alterations are observed around the amyloid plaques of
Alzheimer's disease (AD), little is known about the molecular changes and cellular …

To define the cellular composition and architecture of cutaneous squamous cell carcinoma
(cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and …

The interactions of microorganisms among themselves and with their multicellular host take
place at the microscale, forming complex networks and spatial patterns. Existing technology …

We present deterministic barcoding in tissue for spatial omics sequencing (DBiT-seq) for co-
mapping of mRNAs and proteins in a formaldehyde-fixed tissue slide via next-generation …

Spatial and molecular characteristics determine tissue function, yet high-resolution methods
to capture both concurrently are lacking. Here, we developed high-definition spatial …