Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …

The nucleus is a dynamic environment containing chromatin, membraneless organelles,
and specialized molecular structures at the nuclear membrane. Within the spectrum of DNA …

Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility
of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, here …

High-throughput measurement of cells perturbed using libraries of small molecules, gene
knockouts, or different microenvironmental factors is a key step in functional genomics and …

Nuclear pore complexes (NPC) are the central mediators of nucleocytoplasmic transport.
Increasing evidence shows that many cancer cells have increased numbers of NPCs and …

Ovarian cancer is the most lethal gynecological malignancy worldwide although exponential
progress has been made in its treatment over the last decade. New agents and novel …

The target of rapamycin (TOR) signalling pathway plays a key role in the coordination
between cellular growth and the cell cycle machinery in eukaryotes. The underlying …

CC-115 is a dual inhibitor of the mechanistic target of rapamycin (mTOR) kinase and the
DNA-dependent protein kinase (DNA-PK) that is currently being studied in phase I/II clinical …

Polyploidy is typically described as the condition wherein a cell or organism has more than
two complete sets of chromosomes. Occurrence of polyploidy is a naturally occurring …

Abstract Wnt, PI3K‐Akt‐mTOR, and NF‐κB pathways were reported to be involved in DNA
damage repair (DDR). DDR‐deficient cancers become critically dependent on backup DNA …