The role of mucus on drug transport and its potential to affect therapeutic outcomes

X Murgia, B Loretz, O Hartwig, M Hittinger… - Advanced drug delivery …, 2018 - Elsevier
A layer of mucus covers the surface of all wet epithelia throughout the human body. Mucus is
a hydrogel mainly composed of water, mucins (glycoproteins), DNA, proteins, lipids, and cell …

Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: composition, structure and barrier properties

BC Huck, X Murgia, S Frisch, M Hittinger… - Advanced Drug Delivery …, 2022 - Elsevier
Mucus covers all wet epithelia and acts as a protective barrier. In the airways of the lungs,
the viscoelastic mucus meshwork entraps and clears inhaled materials and efficiently …

Macro-and microrheological properties of mucus surrogates in comparison to native intestinal and pulmonary mucus

BC Huck, O Hartwig, A Biehl, K Schwarzkopf… - …, 2019 - ACS Publications
Mucus is a complex hydrogel that acts as a protective barrier in various parts of the human
body. Both composition and structural properties play a crucial role in maintaining barrier …

To decipher the phytochemical agent and mechanism for Urginea indica mediated green synthesis of Ag nanoparticles and investigation of its antibacterial activity …

B Jena, SS Singh, SK Behera, S Mishra… - Environmental …, 2023 - Elsevier
Abstract Globally, Methicillin-Resistant Staphylococcus aureus bacteraemia is one of the
commonest bloodstream infections associated with clinical complications and high mortality …

Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles

H Yasar, A Biehl, C De Rossi, M Koch, X Murgia… - Journal of …, 2018 - Springer
Abstract Background Messenger RNA (mRNA) has gained remarkable attention as an
alternative to DNA-based therapies in biomedical research. A variety of biodegradable …

Squalenyl hydrogen sulfate nanoparticles for simultaneous delivery of tobramycin and an alkylquinolone quorum sensing inhibitor enable the eradication of P …

DK Ho, X Murgia, C De Rossi, R Christmann… - Angewandte …, 2020 - Wiley Online Library
Elimination of pulmonary Pseudomonas aeruginosa (PA) infections is challenging to
accomplish with antibiotic therapies, mainly due to resistance mechanisms. Quorum sensing …

Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies

EC Arrua, O Hartwig, B Loretz, X Murgia, DK Ho… - International Journal of …, 2023 - Elsevier
Benznidazole, a poorly soluble in water drug, is the first-line medication for the treatment of
Chagas disease, but long treatment periods at high dosages cause several adverse effects …

Recent advances on drug delivery applications of mucopenetrative/mucoadhesive particles: A review

V Puri, VP Kaur, A Singh, C Singh - Journal of Drug Delivery Science and …, 2022 - Elsevier
The human body is made up of various external skin barriers to fight disease and infection.
One such barrier is mucus, which not only protects and lubricates the exposed epithelia by …

Human airway mucus alters susceptibility of Pseudomonas aeruginosa biofilms to tobramycin, but not colistin

L Müller, X Murgia, L Siebenbürger… - Journal of …, 2018 - academic.oup.com
Objectives In the context of cystic fibrosis, Pseudomonas aeruginosa biofilms often develop
in the vicinity of airway mucus, which acts as a protective physical barrier to inhaled matter …

Testing of aerosolized ciprofloxacin nanocarriers on cystic fibrosis airway cells infected with P. aeruginosa biofilms

J Juntke, X Murgia, N Günday Türeli, AE Türeli… - Drug delivery and …, 2021 - Springer
The major pathogen found in the lungs of adult cystic fibrosis (CF) patients is Pseudomonas
aeruginosa, which builds antibiotic-resistant biofilms. Pulmonary delivery of antibiotics by …