BC Huck, X Murgia, S Frisch, M Hittinger… - Advanced Drug Delivery …, 2022 - Elsevier
Mucus covers all wet epithelia and acts as a protective barrier. In the airways of the lungs, the viscoelastic mucus meshwork entraps and clears inhaled materials and efficiently …
BC Huck, O Hartwig, A Biehl, K Schwarzkopf… - …, 2019 - ACS Publications
Mucus is a complex hydrogel that acts as a protective barrier in various parts of the human body. Both composition and structural properties play a crucial role in maintaining barrier …
B Jena, SS Singh, SK Behera, S Mishra… - Environmental …, 2023 - Elsevier
Abstract Globally, Methicillin-Resistant Staphylococcus aureus bacteraemia is one of the commonest bloodstream infections associated with clinical complications and high mortality …
H Yasar, A Biehl, C De Rossi, M Koch, X Murgia… - Journal of …, 2018 - Springer
Abstract Background Messenger RNA (mRNA) has gained remarkable attention as an alternative to DNA-based therapies in biomedical research. A variety of biodegradable …
DK Ho, X Murgia, C De Rossi, R Christmann… - Angewandte …, 2020 - Wiley Online Library
Elimination of pulmonary Pseudomonas aeruginosa (PA) infections is challenging to accomplish with antibiotic therapies, mainly due to resistance mechanisms. Quorum sensing …
EC Arrua, O Hartwig, B Loretz, X Murgia, DK Ho… - International Journal of …, 2023 - Elsevier
Benznidazole, a poorly soluble in water drug, is the first-line medication for the treatment of Chagas disease, but long treatment periods at high dosages cause several adverse effects …
V Puri, VP Kaur, A Singh, C Singh - Journal of Drug Delivery Science and …, 2022 - Elsevier
The human body is made up of various external skin barriers to fight disease and infection. One such barrier is mucus, which not only protects and lubricates the exposed epithelia by …
L Müller, X Murgia, L Siebenbürger… - Journal of …, 2018 - academic.oup.com
Objectives In the context of cystic fibrosis, Pseudomonas aeruginosa biofilms often develop in the vicinity of airway mucus, which acts as a protective physical barrier to inhaled matter …
The major pathogen found in the lungs of adult cystic fibrosis (CF) patients is Pseudomonas aeruginosa, which builds antibiotic-resistant biofilms. Pulmonary delivery of antibiotics by …