Arguably the most defining moment in our lives is fertilization, the point at which we inherit
either an X or a Y chromosome from our father. The profoundly different journeys of male …

The pivotal point of vertebrate sex determination is the development of the gonad into a
testis or ovary, which governs phenotypic sex through the production of hormones. The …

Research into the lives of animals in their natural environments has revealed a rich tapestry
of complex social relationships and previously unsuspected social and mating systems. The …

Sex determination in mammals directs an initially bipotential gonad to differentiate into either
a testis or an ovary. This decision is triggered by the expression of the sex-determining gene …

Sex-specific gonadal development starts with formation of the bipotential gonad, which then
differentiates into either a mature testis or an ovary. This process is dependent on activation …

Die fortgesetzte Suche nach dem einzelnen ‚geschlechtsdeterminierenden Gen ': SRY als
TDF? 250 Downstream von SRY–weitere Gene, die hierarchisch unterhalb von SRY als an …

Sex-determining region Y (Sry) is the crucial gene that initiates male sex determination in
most mammals. Although several components of the pathway regulating sexual …

The gonad is a unique biological system for studying cell-fate decisions. However, major
questions remain regarding the identity of somatic progenitor cells and the transcriptional …

Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly
understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 …

Heritable diseases are caused by germ-line mutations that, despite tissuewide presence,
often lead to tissue-specific pathology. Here, we make a systematic analysis of the link …