This literature review investigates the significant overlap between myelin-repair signaling
pathways and pathways known to contribute to hallmark pathologies of Alzheimer's disease …

White matter (WM) microstructural properties change across the adult lifespan and with
neuronal diseases. Understanding microstructural changes due to aging is paramount to …

Myelin water imaging is a quantitative neuroimaging technique that provides the myelin
water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular …

Myelin loss and iron accumulation are cardinal features of aging and various
neurodegenerative diseases. Oligodendrocytes incorporate iron as a metabolic substrate for …

BACKGROUND: It is unknown whether hypertension plays any role in cerebral myelination.
To fill this knowledge gap, we studied 90 cognitively unimpaired adults, age range 40 to 94 …

It is well-established that higher socioeconomic status (SES) is associated with improved
brain health. However, the effects of SES across different life stages on brain structure and …

Purpose Neurite orientation dispersion and density imaging (NODDI) provides measures of
neurite density and dispersion through computation of the neurite density index (NDI) and …

Adequate cerebral blood flow (CBF) is essential to a healthy central nervous system (CNS).
Previous work suggests that CBF differs between men and women, and declines with age …

The relationship between brain microstructure and aging has been the subject of intense
study, with diffusion MRI perhaps the most effective modality for elucidating these …

Quantitative MRI modalities, such as diffusion tensor imaging (DTI) or magnetization transfer
imaging (MTI) are sensitive to the neuronal effects of aging of the cerebral white matter …