Random DNA barcodes are a versatile tool for tracking cell lineages, with applications
ranging from development to cancer to evolution. Here, we review and critically evaluate …

Massively parallel sequencing technologies have long been used in both basic research
and clinical routine. The recent introduction of digital sequencing has made previously …

Archiving data in synthetic DNA offers unprecedented storage density and longevity.
Handling and storage introduce errors and biases into DNA-based storage systems …

CRISPR genome editing approaches theoretically enable researchers to define the function
of each human gene in specific cell types, but challenges remain to efficiently perform …

Efficient error-correction codes are crucial for realizing DNA's potential as a long-lasting,
high-density storage medium for digital data. At the same time, new workflows promising low …

Abstract Hybridization Chain Reaction (HCR) is a technique to generate a linear
polymerization of oligonucleotide hairpins, used in multiple molecular biology methods. The …

Generating genetic diversity lies at the heart of directed evolution which has been widely
used to engineer genetic parts and gene circuits in synthetic biology. With the ever …

A comprehensive error analysis of DNA-stored data during processing, such as DNA
synthesis and sequencing, is crucial for reliable DNA data storage. Both synthesis and …

Massively parallel sequencing (MPS) is increasingly applied in forensic short tandem repeat
(STR) analysis. The presence of stutter artefacts and other PCR or sequencing errors in the …

The development of CRISPR genetic screening tools has improved functional genomics, as
these tools enable precise genomic editing, provide broad access to genomic regions …