Although the use of oral administration of pharmacological all-trans retinoic acid (ATRA)
concentration in acute promyelocytic leukaemia (APL) patients was approved for over 20 …

Abstract The 'Retinoic Acid-Inducible G-protein-coupled receptors' or RAIG are a group
comprising the four orphan receptors GPRC5A, GPRC5B, GPRC5C and GPRC5D. As the …

Background: The precise details of pancreatic ductal adenocarcinoma (PDAC)
pathogenesis are still insufficiently known, requiring the use of higthroughput methods …

Bladder cancer leads to approximately 13 000 deaths annually in the United States. Early
disease is often treated with minimal morbidity and has good prognosis, while the opposite …

Targeted drugs are less toxic than traditional chemotherapeutic therapies; however, the
proportion of patients that benefit from these drugs is often smaller. A marker that confidently …

Metastatic cancers commonly activate adaptive chemotherapy resistance, attributed to both
microenvironment‐dependent phenotypic plasticity and genetic characteristics of cancer …

Purpose: Epigenetic events are a critical factor contributing to cancer development. The
purpose of this study was to identify tumor suppressor genes silenced by DNA methylation …

This study demonstrates, through a combination of stringent screening methods and
thorough validation, that it is possible to identify transmembrane proteins preferentially …

Background Lung cancers develop via multiple genetic and epigenetic changes, including
inactivation of tumor suppressor genes. We previously cloned human G protein–coupled …

Abstract GPRC5A is a G-protein–coupled receptor expressed in lung tissue but repressed in
most human lung cancers. Studies in Gprc5a−/− mice have established its role as a tumor …