Multiple myeloma with high-risk cytogenetics and its treatment approach

I Hanamura - International Journal of Hematology, 2022 - Springer
Despite substantial advances in anti-myeloma treatments, early recurrence and death
remain an issue in certain subpopulations. Cytogenetic abnormalities (CAs) are the most …

International consensus statement on allergy and rhinology: sinonasal tumors

EC Kuan, EW Wang, ND Adappa… - International forum of …, 2024 - Wiley Online Library
Background Sinonasal neoplasms, whether benign and malignant, pose a significant
challenge to clinicians and represent a model area for multidisciplinary collaboration in …

Teclistamab in relapsed or refractory multiple myeloma

P Moreau, AL Garfall, NWCJ van de Donk… - … England Journal of …, 2022 - Mass Medical Soc
Background Teclistamab is a T-cell–redirecting bispecific antibody that targets both CD3
expressed on the surface of T cells and B-cell maturation antigen expressed on the surface …

Ciltacabtagene autoleucel, an anti–B-cell maturation antigen chimeric antigen receptor T-cell therapy, for relapsed/refractory multiple myeloma: CARTITUDE-1 2-year …

T Martin, SZ Usmani, JG Berdeja, M Agha… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE CARTITUDE-1, a phase Ib/II study evaluating the safety and efficacy of
ciltacabtagene autoleucel (cilta-cel) in heavily pretreated patients with relapsed/refractory …

Second revision of the International Staging System (R2-ISS) for overall survival in multiple myeloma: a European Myeloma Network (EMN) report within the …

M D'agostino, DA Cairns, JJ Lahuerta… - Journal of clinical …, 2022 - ascopubs.org
PURPOSE Patients with newly diagnosed multiple myeloma (NDMM) show heterogeneous
outcomes, and approximately 60% of them are at intermediate-risk according to the Revised …

Prevalence of smoldering multiple myeloma based on nationwide screening

S Thorsteinsdóttir, GK Gíslason, T Aspelund… - Nature medicine, 2023 - nature.com
Smoldering multiple myeloma (SMM) is an asymptomatic precursor to multiple myeloma.
Here we define the epidemiological characteristics of SMM in the general population in …

Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance

C Botta, C Perez, M Larrayoz, N Puig… - Nature …, 2023 - nature.com
Tumor recognition by T cells is essential for antitumor immunity. A comprehensive
characterization of T cell diversity may be key to understanding the success of …

Gaps and opportunities in the treatment of relapsed-refractory multiple myeloma: Consensus recommendations of the NCI Multiple Myeloma Steering Committee

S Kumar, L Baizer, NS Callander, SA Giralt… - Blood cancer …, 2022 - nature.com
A wide variety of new therapeutic options for Multiple Myeloma (MM) have recently become
available, extending progression-free and overall survival for patients in meaningful ways …

How to Treat High-Risk Myeloma at Diagnosis and Relapse.

J Caro, S Al Hadidi, S Usmani, AJ Yee… - American Society of …, 2021 - europepmc.org
Survival in multiple myeloma has improved greatly during the past 2 decades, but this
change has primarily benefited patients who have standard-risk disease. Patients with high …

Metabolomic biomarkers of multiple myeloma: A systematiс review

VG Varzieva, NV Mesonzhnik, IS Ilgisonis… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Multiple myeloma is an incurable malignancy of clonal plasma cells. Various diagnostic
methods are used in parallel to accurately determine stage and severity of the disease …