Chemical aspects of human and environmental overload with fluorine
Over the last 100–120 years, due to the ever-increasing importance of fluorine-containing
compounds in modern technology and daily life, the explosive development of the …
compounds in modern technology and daily life, the explosive development of the …
Ferrocene-containing hybrids as potential anticancer agents: Current developments, mechanisms of action and structure-activity relationships
Cancer is one of the most fatal threatens to human health throughout the world. The major
challenges in the control and eradication of cancers are the continuous emergency of drug …
challenges in the control and eradication of cancers are the continuous emergency of drug …
Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy
Protein kinases have grown over the past few years as a crucial target for different cancer
types. With the multifactorial nature of cancer, and the fast development of drug resistance …
types. With the multifactorial nature of cancer, and the fast development of drug resistance …
New 1, 2, 3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization
HHH Mohammed, AA Abd El-Hafeez… - Journal of enzyme …, 2022 - Taylor & Francis
Abstract A series of novel 1, 2, 3-triazole-linked ciprofloxacin-chalcones 4a-j were
synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable anti …
synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable anti …
Topoisomerase II inhibitors design: Early studies and new perspectives
The DNA topoisomerase enzymes are widely distributed throughout all spheres of life and
are necessary for cell function. Numerous antibacterial and cancer chemotherapeutic drugs …
are necessary for cell function. Numerous antibacterial and cancer chemotherapeutic drugs …
Design, synthesis, and biological evaluation of novel ciprofloxacin derivatives as potential anticancer agents targeting topoisomerase II enzyme
A series of novel ciprofloxacin (CP) derivatives substituted at the N-4 position with
biologically active moieties were designed and synthesised. 14 compounds were 1.02-to …
biologically active moieties were designed and synthesised. 14 compounds were 1.02-to …
Novel and structurally diversified bacterial DNA gyrase inhibitors discovered through a fluorescence-based high-throughput screening assay
EE Alfonso, Z Deng, D Boaretto, BL Hood… - ACS Pharmacology & …, 2022 - ACS Publications
Bacterial DNA gyrase, a type IIA DNA topoisomerase that plays an essential role in bacterial
DNA replication and transcription, is a clinically validated target for discovering and …
DNA replication and transcription, is a clinically validated target for discovering and …
Insights on fluoroquinolones in cancer therapy: Chemistry and recent developments
Cancer is a very risky life-threatening disease having most formidable afflictions in the world.
Several anticancer agents are commercially accessible, however, the emergence of …
Several anticancer agents are commercially accessible, however, the emergence of …
Recent development of fluoroquinolone derivatives as anticancer agents
J Nowakowska, D Radomska, R Czarnomysy… - …, 2024 - pmc.ncbi.nlm.nih.gov
Cancer is the second leading cause of death in the world following cardiovascular disease.
Its treatment, including radiation therapy and surgical removal of the tumour, is based on …
Its treatment, including radiation therapy and surgical removal of the tumour, is based on …
[HTML][HTML] In silico drug repurposing in COVID-19: A network-based analysis
The SARS-CoV-2 pandemic is a worldwide public health emergency. Despite the beginning
of a vaccination campaign, the search for new drugs to appropriately treat COVID-19 …
of a vaccination campaign, the search for new drugs to appropriately treat COVID-19 …