[HTML][HTML] Life of RISC: Formation, action, and degradation of RNA-induced silencing complex
Small RNAs regulate a wide variety of biological processes by repressing the expression of
target genes at the transcriptional and post-transcriptional levels. To achieve these …
target genes at the transcriptional and post-transcriptional levels. To achieve these …
The intricate balance between microRNA‐induced mRNA decay and translational repression
P Naeli, T Winter, AP Hackett, L Alboushi… - The FEBS …, 2023 - Wiley Online Library
Post‐transcriptional regulation of messenger RNAs (mRNAs)(ie, mechanisms that control
translation, stability and localization) is a critical focal point in spatiotemporal regulation of …
translation, stability and localization) is a critical focal point in spatiotemporal regulation of …
SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation
Viruses evade the innate immune response by suppressing the production or activity of
cytokines such as type I interferons (IFNs). Here we report the discovery of a mechanism by …
cytokines such as type I interferons (IFNs). Here we report the discovery of a mechanism by …
Mechanistic insights into microRNA-mediated gene silencing
TF Duchaine, MR Fabian - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
MicroRNAs (miRNAs) posttranscriptionally regulate gene expression by repressing protein
synthesis and exert a broad influence over development, physiology, adaptation, and …
synthesis and exert a broad influence over development, physiology, adaptation, and …
Phosphorylation and signal transduction pathways in translational control
CG Proud - Cold Spring Harbor perspectives in biology, 2019 - cshperspectives.cshlp.org
Protein synthesis, including the translation of specific messenger RNAs (mRNAs), is
regulated by extracellular stimuli such as hormones and by the levels of certain nutrients …
regulated by extracellular stimuli such as hormones and by the levels of certain nutrients …
[HTML][HTML] Ciphers and executioners: how 3′-untranslated regions determine the fate of messenger RNAs
VK Mayya, TF Duchaine - Frontiers in Genetics, 2019 - frontiersin.org
The sequences and structures of 3′-untranslated regions (3′ UTRs) of messenger RNAs
govern their stability, localization, and expression. 3′ UTR regulatory elements are …
govern their stability, localization, and expression. 3′ UTR regulatory elements are …
miR-223 exerts translational control of proatherogenic genes in macrophages
Background: A significant burden of atherosclerotic disease is driven by inflammation.
Recently, microRNAs (miRNAs) have emerged as important factors driving and protecting …
Recently, microRNAs (miRNAs) have emerged as important factors driving and protecting …
Regulatory mechanism of miR-722 on C5aR1 and its functions against bacterial inflammation in half-smooth tongue sole (Cynoglossus semilaevis)
H Liu, S Tan, Y Chen, X Chen, X Liu, Z Li… - International Journal of …, 2023 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs involved in various biological processes,
including immunity. Previously, we investigated the miRNAs of half-smooth tongue sole …
including immunity. Previously, we investigated the miRNAs of half-smooth tongue sole …
[HTML][HTML] Translational repression of NMD targets by GIGYF2 and EIF4E2
Translation of messenger RNAs (mRNAs) with premature termination codons produces
truncated proteins with potentially deleterious effects. This is prevented by nonsense …
truncated proteins with potentially deleterious effects. This is prevented by nonsense …
[HTML][HTML] The regulatory properties of the Ccr4–Not complex
N Chalabi Hagkarim, RJ Grand - Cells, 2020 - mdpi.com
The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on
TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts …
TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts …