Cardiac glycosides (CGs) are secondary compounds found in plants and amphibians and
are widely distributed in nature with potential cardiovascular action. Their mechanism is …

The search for endogenous digitalis has led to the isolation of ouabain as well as several
additional cardiotonic steroids of the cardenolide and bufadienolide type from blood …

Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in
mammals. Among them are the hydrophilic cardenolide ouabain and the more hydrophobic …

The Na, K-ATPase is the membrane “pump” that generates the Na+ and K+ gradients across
the plasma membrane that drives many physiological processes. This enzyme is highly …

It is well accepted that inhibition of the Na, K-ATPase in the heart, through effects on the
Na/Ca exchanger, raises the intracellular Ca 2+ concentration and strengthens cardiac …

Cardiac glycosides have been used for decades to treat congestive heart failure. The recent
identification of cardiotonic steroids such as ouabain, digoxin, marinobufagenin, and …

The central nervous system has a key role in regulating the circulatory system by modulating
the sympathetic and parasympathetic nervous systems, pituitary hormone release, and the …

[Frontiers in Bioscience 10, 2373-2396, September 1, 2005] 2373 NEURONAL FUNCTION AND
ALPHA3 ISOFORM OF THE Na/K-ATPase Maxim Do Page 1 [Frontiers in Bioscience 10 …

The Na, K-ATPase contains a binding site for cardiac glycosides, such as ouabain, digoxin,
and digitoxin, which is highly conserved among species ranging from Drosophila to humans …

In this brief review we discuss some aspects of the Na+ pump and its roles in mediating the
effects of ouabain and endogenous ouabain (EO): i) in regulating the cytosolic Ca 2+ …