Toxic effects and molecular mechanism of doxorubicin on different organs–an update

K Renu, LP Pureti, B Vellingiri… - Toxin …, 2022 - Taylor & Francis
Doxorubicin is an extensively used anti-neoplastic drug used for solid and hematogenous
cancer since the 1950s, and its usage is limited due to its toxic effects upon various organs …

Mechanisms of doxorubicin-mediated reproductive toxicity–a review

UP Mohan, TP PB, STA Iqbal, S Arunachalam - Reproductive Toxicology, 2021 - Elsevier
The anticancer drug doxorubicin has been associated with several adverse side-effects
including reproductive toxicity in both genders. The current review has complied the …

[HTML][HTML] Effects of chemotherapeutic agents on male germ cells and possible ameliorating impact of antioxidants

S Ghafouri-Fard, H Shoorei, A Abak, M Seify… - Biomedicine & …, 2021 - Elsevier
Abstract Treatment of cancer in young adults is associated with several side effects,
particularly in the reproductive system. Detrimental effects of chemotherapy on the germ …

Role of flavonoids against adriamycin toxicity

MD Navarro-Hortal, A Varela-López… - Food and Chemical …, 2020 - Elsevier
Abstract Doxorubicin (DOX), or adriamycin, is an anthracycline antineoplastic drug widely
used in the chemotherapy of a large variety of cancers due to its potency and action …

Does air pollution exposure affect semen quality? Evidence from a systematic review and meta-analysis of 93,996 Chinese men

J Liu, Y Dai, R Li, J Yuan, Q Wang… - Frontiers in Public Health, 2023 - frontiersin.org
Background Air pollution may impair male fertility, but it remains controversial whether air
pollution affects semen quality until now. Objectives We undertake a meta-analysis to …

Protective effects of crimson snapper scales peptides against oxidative stress on Drosophila melanogaster and the action mechanism

X Cai, S Chen, J Liang, M Tang, S Wang - Food and Chemical Toxicology, 2021 - Elsevier
Peptides derived from crimson snapper scales (CSSPs) were reported to possess excellent
free radical scavenging activities in vitro. In present study, the anti-aging and anti-oxidative …

Statins and male fertility: is there a cause for concern?

TS Omolaoye, MO Halabi, M Mubarak, AC Cyril… - Toxics, 2022 - mdpi.com
The well-known 3-hydroxyl 3-methyl glutaryl-Coenzyme A reductase inhibitors, called
statins, have been the main medication used in the treatment of hypercholesterolemia and …

The role of different compounds on the integrity of blood-testis barrier: A concise review based on in vitro and in vivo studies

S Ghafouri-Fard, H Shoorei, M Mohaqiq, SHA Raza… - Gene, 2021 - Elsevier
Sertoli cells are “nurturing cells''in the seminiferous tubules of the testis which have essential
roles in the development, proliferation and differentiation of germ cells. These cells also …

mTORC1/C2 regulate spermatogenesis in Eriocheir sinensis via alterations in the actin filament network and cell junctions

ZF Li, SL Hao, LM Wang, HY Qi, JM Wang… - Cell and Tissue …, 2022 - Springer
Spermatogenesis is a finely regulated process of germ cell proliferation and differentiation
that leads to the production of sperm in seminiferous tubules. Although the mammalian …

Effects of clinical medications on male fertility and prospects for stem cell therapy

P Mo, Z Zhao, X Ke, Y Fan, C Li - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
An increasing number of men require long-term drug therapy for various diseases. However,
the effects of long-term drug therapy on male fertility are often not well evaluated in clinical …