[HTML][HTML] Metabolism, toxicity and anticancer activities of arsenic compounds

I Khairul, QQ Wang, YH Jiang, C Wang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
A variety of studies indicated that inorganic arsenic and its methylated metabolites have
paradoxical effects, namely, carcinogenic and anticancer effects. Epidemiological studies …

Mechanistic understanding of the toxic effects of arsenic and warfare arsenicals on human health and environment

S Muzaffar, J Khan, R Srivastava, MS Gorbatyuk… - Cell Biology and …, 2023 - Springer
Worldwide, more than 200 million people are estimated to be exposed to unsafe levels of
arsenic. Chronic exposure to unsafe levels of groundwater arsenic is responsible for …

Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk

A Kumar, M Ali, R Kumar, M Kumar, P Sagar… - Scientific reports, 2021 - nature.com
Reportedly, 300 million people worldwide are affected by the consumption of arsenic
contaminated groundwater. India prominently figures amongst them and the state of Bihar …

The role of mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) in inflammation

U Moens, S Kostenko, B Sveinbjørnsson - Genes, 2013 - mdpi.com
Mitogen-activated protein kinase (MAPK) pathways are implicated in several cellular
processes including proliferation, differentiation, apoptosis, cell survival, cell motility …

Impaired Notch‐MKP‐1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology

BC Melnik, G Plewig - Experimental dermatology, 2013 - Wiley Online Library
Recent findings in familial hidradenitis suppurativa (HS) demonstrated loss‐of‐function
mutations of components of the γ‐secretase (GS) complex leading to decreased protease …

Toxicity mechanisms of arsenic that are shared with neurodegenerative diseases and cognitive impairment: Role of oxidative stress and inflammatory responses

C Escudero-Lourdes - Neurotoxicology, 2016 - Elsevier
Arsenic (As) is a worldwide naturally occurring metalloid. Human chronic exposure to
inorganic As compounds (iAs), which are at the top of hazardous substances (ATSDR …

The mechanistic basis of arsenicosis: pathogenesis of skin cancer

KM Hunt, RK Srivastava, CA Elmets, M Athar - Cancer letters, 2014 - Elsevier
Significant amounts of arsenic have been found in the groundwater of many countries
including Argentina, Bangladesh, Chile, China, India, Mexico, and the United States with an …

Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules

JR Child, Q Chen, DW Reid, S Jagannathan… - Rna, 2021 - rnajournal.cshlp.org
Stress granules (SGs) are membraneless organelles composed of mRNAs and RNA binding
proteins which undergo assembly in response to stress-induced inactivation of translation …

Assessment of arsenic exposure in the population of Sabalpur village of Saran District of Bihar with mitigation approach

A Kumar, R Kumar, MS Rahman, M Ali… - … Science and Pollution …, 2021 - Springer
Arsenic poisoning through groundwater is the world's greatest normal groundwater
catastrophe which got an immense effect on worldwide general wellbeing. India is …

Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis

RA Panganiban, HR Park, M Sun… - Proceedings of the …, 2019 - National Acad Sciences
Sensing misfolded proteins in the endoplasmic reticulum (ER), cells initiate the ER stress
response and, when overwhelmed, undergo apoptosis. However, little is known about how …