Immunotherapies are revolutionizing the clinical management of a wide range of cancers.
However, intrinsic or acquired unresponsiveness to immunotherapies does occur due to the …

EZH2 is an epigenetic regulator that methylates lysine 27 on histone H3 (H3K27) and is
closely related to the development and metastasis of tumors. It often shows gain-of-function …

ABSTRACT Polycomb repressive complex 2 (PRC2) catalyzes methylation of histone H3 on
lysine 27 and is required for normal development of complex eukaryotes. The nature of that …

Background. The prognosis of non‐small‐cell lung cancer (NSCLC) has not been
significantly improved. In the past several years, research on epigenetics is in full swing …

There are unique stressors in the spaceflight environment. Exposure to such stressors may
be associated with adverse effects on astronauts' health, including increased cancer and …

BACKGROUND Sex determining region Y-box 2 (SOX2) can promote squamous cell
carcinoma (SSC) because it regulates the migration and invasion of several different types …

Abstract Enhancer of Zeste Homologue 2 (EZH2) as a histone methyltransferase
epigenetically regulates laryngeal carcinoma (LGC) progression. The present study sought …

Significant improvements in clinical outcomes for lung cancer patients have been achieved
over the past decade, and this is a result of the introduction of targeted therapies in …

Esophageal cancer has always been one of the major malignant tumor types affecting the
health of the Chinese population. Metastasis‑associated protein 1 (MTA1), SOX4 and …

Background Epithelial–mesenchymal transition plays a crucial role in cancer progression
and is a significant prognosticator for postoperative survival in patients with lung cancer …