X-linked hypophosphataemia (XLH) is the most common cause of inherited phosphate
wasting and is associated with severe complications such as rickets, lower limb deformities …

X-linked hypophosphataemia (XLH) is the most frequent cause of hypophosphataemia-
associated rickets of genetic origin and is associated with high levels of the phosphaturic …

Abnormalities of enamel and dentine are caused by a variety of interacting factors ranging
from genetic defects to environmental insults. The genetic changes associated with some …

The major mineralized tissues are bone and teeth, which share several mechanisms
governing their development and mineralization. This crossover includes the hormones that …

Matrix metalloproteinases (MMPs) are a group of more than 25 secreted and membrane
bound enzymes that represent class of enzymes responsible for degradation of pericellular …

Teeth are mineralized organs composed of three unique hard tissues, enamel, dentin, and
cementum, and supported by the surrounding alveolar bone. Although odontogenesis differs …

X-linked hypophosphatemia (XLH) is a rare genetic skeletal disease where increased
phosphate wasting in the kidney leads to hypophosphatemia and prevents normal …

Mineralization defects like amelogenesis imperfecta are often of hereditary origin. This
article reviews the diagnostic findings and summarizes the suggested treatment …

Screening gene function in vivo is a powerful approach to discover novel drug targets. We
present high-throughput screening (HTS) data for 3 762 distinct global gene knockout (KO) …

The FAM20 family of secreted proteins consists of three members (FAM20A, FAM20B, and
FAM20C) recently linked to developmental disorders suggesting roles for FAM20 proteins in …