Aseptic meningitis

P Tattevin, S Tchamgoué, A Belem, F Bénézit… - Revue …, 2019 - Elsevier
Aseptic meningitis is defined as meningeal inflammation–ie cerebrospinal fluid (CSF)
pleocytosis≥ 5 cells/mm 3–not related to an infectious process. Etiologies of aseptic …

Leptomeningeal spread in glioblastoma: diagnostic and therapeutic challenges

C Birzu, S Tran, F Bielle, M Touat, K Mokhtari… - The …, 2020 - academic.oup.com
Background Glioblastoma (GBM) is the most common and aggressive primary malignant
brain tumor. Leptomeningeal spread (LMS) is a severe complication of GBM, raising …

[HTML][HTML] EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours

E Le Rhun, M Weller, D Brandsma, M Van den Bent… - Annals of oncology, 2017 - Elsevier
These EANO–ESMO joint recommendations for the diagnosis and treatment of
leptomeningeal metastasis (LM) from solid cancers represent the first European guideline …

Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer

Y Togashi, K Masago, S Masuda, T Mizuno… - Cancer chemotherapy …, 2012 - Springer
Purpose Several cases have been reported in which central nervous system (CNS)
metastases of non-small cell lung cancer (NSCLC) resistant to gefitinib were improved by …

[HTML][HTML] Leptomeningeal metastasis from solid tumours: EANO–ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

E Le Rhun, M Weller, M van den Bent, D Brandsma… - ESMO open, 2023 - Elsevier
These joint European Association of Neuro-Oncology (EANO)–European Society for
Medical Oncology (ESMO) recommendations for the diagnosis and treatment of …

Breast cancer leptomeningeal metastasis: propensity of breast cancer subtypes for leptomeninges and the analysis of factors influencing survival

A Niwińska, H Rudnicka, M Murawska - Medical oncology, 2013 - Springer
The aim of the study was to define biological subtypes of breast cancer that have the
propensity to metastasize to the leptomeninges and to assess factors influencing survival …

A pilot study of bevacizumab combined with etoposide and cisplatin in breast cancer patients with leptomeningeal carcinomatosis

PF Wu, CH Lin, CH Kuo, WW Chen, DC Yeh, HW Liao… - BMC cancer, 2015 - Springer
Background Elevated vascular endothelial growth factor (VEGF) was associated with poor
prognosis in leptomeningeal carcinomatosis and anti-angiogenic therapy was found to …

Systemic treatments for brain metastases from breast cancer, non-small cell lung cancer, melanoma and renal cell carcinoma: an overview of the literature

G Lombardi, AL Di Stefano, P Farina, V Zagonel… - Cancer treatment …, 2014 - Elsevier
The frequency of metastatic brain tumors has increased over recent years; the primary
tumors most involved are breast cancer, lung cancer, melanoma and renal cell carcinoma …

Prolonged survival of a patient with metastatic leptomeningeal melanoma treated with BRAF inhibition-based therapy: a case report

DW Kim, E Barcena, UN Mehta, ML Rohlfs, AJ Kumar… - BMC cancer, 2015 - Springer
Background Leptomeningeal metastasis of melanoma is a devastating complication with a
grave prognosis, and there are no known effective standard treatments. Although selective …

Transependymal cerebrospinal fluid flow: opportunity for drug delivery?

J Casaca-Carreira, Y Temel, SA Hescham… - Molecular …, 2018 - Springer
Drug delivery to the central nervous system (CNS) is complicated by the blood-brain barrier.
As a result, many agents that are found to be potentially effective at their site of action cannot …