Cellular RNAs are naturally decorated with a variety of chemical modifications. The structural diversity of the modified nucleosides provides regulatory potential to sort groups of …
Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation 1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …
RNA modifications are integral to the regulation of RNA metabolism. One abundant mRNA modification is N 6-methyladenosine (m6A), which affects various aspects of RNA …
Autism spectrum disorders (ASDs) and related neurological disorders are associated with mutations in many genes affecting the ratio between neuronal excitation and inhibition …
Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation, transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins …
Neurons localize mRNAs near synapses where their translation can be regulated by synaptic demand and activity. Differences in the 3′ UTRs of mRNAs can change their …
The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we …
Abstract N 6-methyladenosine (m6A) is the most prevalent and reversible internal modification in mammalian messenger and noncoding RNAs. We report here that human …