Treg heterogeneity, function, and homeostasis

D Shevyrev, V Tereshchenko - Frontiers in immunology, 2020 - frontiersin.org
T-regulatory cells (Tregs) represent a unique subpopulation of helper T-cells by maintaining
immune equilibrium using various mechanisms. The role of T-cell receptors (TCR) in …

Interferon-gamma at the crossroads of tumor immune surveillance or evasion

F Castro, AP Cardoso, RM Gonçalves, K Serre… - Frontiers in …, 2018 - frontiersin.org
Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …

Observation of Bose-Einstein condensation in a dilute atomic vapor

MH Anderson, JR Ensher, MR Matthews, CE Wieman… - science, 1995 - science.org
A Bose-Einstein condensate was produced in a vapor of rubidium-87 atoms that was
confined by magnetic fields and evaporatively cooled. The condensate fraction first …

Interferon-γ: an overview of signals, mechanisms and functions

K Schroder, PJ Hertzog, T Ravasi… - Journal of Leucocyte …, 2004 - academic.oup.com
Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …

Development of TH1 CD4+ T Cells Through IL-12 Produced by Listeria-Induced Macrophages

CS Hsieh, SE Macatonia, CS Tripp, SF Wolf, A O'Garra… - Science, 1993 - science.org
Development of the appropriate CD4+ T helper (TH) subset during an immune response is
important for disease resolution. With the use of naive, ovalbumin-specific αβ T cell receptor …

Cellular responses to interferon-γ

U Boehm, T Klamp, M Groot… - Annual review of …, 1997 - annualreviews.org
▪ Abstract The phytohemagglutinin-induced virus-inhibitor may, however, be produced in
white cells in response to a stimulation of cellular RNA synthesis and may be a feedback …

How cells respond to interferons

GR Stark, IM Kerr, BRG Williams… - Annual review of …, 1998 - annualreviews.org
Interferons play key roles in mediating antiviral and antigrowth responses and in modulating
immune response. The main signaling pathways are rapid and direct. They involve tyrosine …

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

DF Fiorentino, MW Bond, TR Mosmann - The Journal of experimental …, 1989 - rupress.org
A cytokine synthesis inhibitory factor (CSIF) is secreted by Th2 clones in response to Con A
or antigen stimulation, but is absent in supernatants from Con A-induced Th1 clones. CSIF …

The interferons and their receptors—distribution and regulation

NA De Weerd, T Nguyen - Immunology and cell biology, 2012 - Wiley Online Library
The interferons (IFNs) were originally described over 50 years ago, identified by their ability
to confer viral resistance to cells. We now know that they are much more than just anti‐viral …

How do regulatory T cells work?

A Corthay - Scandinavian journal of immunology, 2009 - Wiley Online Library
CD4+ T cells are commonly divided into regulatory T (Treg) cells and conventional T helper
(Th) cells. Th cells control adaptive immunity against pathogens and cancer by activating …