Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle

S Voisin, K Seale, M Jacques, S Landen… - Aging …, 2024 - Wiley Online Library
Exercise training prevents age‐related decline in muscle function. Targeting epigenetic
aging is a promising actionable mechanism and late‐life exercise mitigates epigenetic aging …

[HTML][HTML] Aging clocks based on accumulating stochastic variation

DH Meyer, B Schumacher - Nature Aging, 2024 - nature.com
Aging clocks have provided one of the most important recent breakthroughs in the biology of
aging, and may provide indicators for the effectiveness of interventions in the aging process …

Quantifying the stochastic component of epigenetic aging

H Tong, VB Dwaraka, Q Chen, Q Luo, JA Lasky-Su… - Nature Aging, 2024 - nature.com
DNA methylation clocks can accurately estimate chronological age and, to some extent, also
biological age, yet the process by which age-associated DNA methylation (DNAm) changes …

Histone mark age of human tissues and cells

LP de Lima Camillo, MH Asif, S Horvath, E Larschan… - bioRxiv, 2023 - biorxiv.org
Background: Aging involves intricate epigenetic changes, with histone modifications playing
a pivotal role in dynamically regulating gene expression. Our research comprehensively …

Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape

S Liesenfelder, MH Elsafi Mabrouk, J Iliescu… - bioRxiv, 2024 - biorxiv.org
Aging is reflected by genome-wide DNA methylation changes, but it is largely unclear how
these epigenetic modifications are regulated. In this study, we explored the possibility to …

Gene regulatory interactions limit the gene expression diversity

O Levy, S Tripathi, SD Pope, YY Liu… - arXiv preprint arXiv …, 2023 - arxiv.org
The diversity of expressed genes plays a critical role in cellular specialization, adaptation to
environmental changes, and overall cell functionality. This diversity varies dramatically …