Function of alternative splicing

O Kelemen, P Convertini, Z Zhang, Y Wen, M Shen… - Gene, 2013 - Elsevier
Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

ASTALAVISTA: dynamic and flexible analysis of alternative splicing events in custom gene datasets

S Foissac, M Sammeth - Nucleic acids research, 2007 - academic.oup.com
In the process of establishing more and more complete annotations of eukaryotic genomes,
a constantly growing number of alternative splicing (AS) events has been reported over the …

Pathways and genes involved in steroid hormone metabolism in male pigs: A review and update

A Robic, T Faraut, A Prunier - The Journal of steroid biochemistry and …, 2014 - Elsevier
This paper reviews state-of-the-art knowledge on steroid biosynthesis pathways in the pig
and provides an updated characterization of the porcine genes involved in these pathways …

De novo transcriptome assembly of an Antarctic nematode for the study of thermal adaptation in marine parasites

M Palomba, P Libro, J Di Martino, X Roca-Geronès… - Scientific Data, 2023 - nature.com
Understanding the genomic underpinnings of thermal adaptation is a hot topic in eco-
evolutionary studies of parasites. Marine heteroxenous parasites have complex life cycles …

MD–ligand–receptor: a high-performance computing tool for characterizing ligand–receptor binding interactions in molecular dynamics trajectories

M Pieroni, F Madeddu, J Di Martino, M Arcieri… - International Journal of …, 2023 - mdpi.com
Molecular dynamics simulation is a widely employed computational technique for studying
the dynamic behavior of molecular systems over time. By simulating macromolecular …

Identification and functional characterization of two new transcriptional variants of the human p63 gene

M Mangiulli, A Valletti, MF Caratozzolo… - Nucleic acids …, 2009 - academic.oup.com
Abstract p63 belongs to a family of transcription factors, which, while demonstrating striking
conservation of functional domains, regulate distinct biological functions. Its principal role is …

LncRNA Uc003xsl. 1-mediated activation of the NFκB/IL8 axis promotes progression of triple-negative breast cancer

Y Xu, W Ren, Q Li, C Duan, X Lin, Z Bi, K You, Q Hu… - Cancer research, 2022 - AACR
Aberrant activation of NFκB orchestrates a critical role in tumor carcinogenesis; however, the
regulatory mechanisms underlying this activation are not fully understood. Here we report …

Increased transcript diversity: novel splicing variants of Machado–Joseph Disease gene (ATXN3)

C Bettencourt, C Santos, R Montiel, MC Costa… - Neurogenetics, 2010 - Springer
Machado–Joseph disease (MJD) is a late-onset neurodegenerative disorder that presents
clinical heterogeneity not completely explained by its causative mutation. MJD is caused by …

Computational methods for ab initio and comparative gene finding

E Picardi, G Pesole - Data mining techniques for the life sciences, 2010 - Springer
High-throughput DNA sequencing is increasing the amount of public complete genomes
even though a precise gene catalogue for each organism is not yet available. In this context …

Integrated de novo transcriptome of Culex pipiens mosquito larvae as a resource for genetic control strategies

V Mastrantonio, P Libro, J Di Martino, M Matera… - Scientific Data, 2024 - nature.com
We present a de novo transcriptome of the mosquito vector Culex pipiens, assembled by
sequences of susceptible and insecticide resistant larvae. The high quality of the assembly …