Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …

Advances in self-organizing cardiac organoids to recapitulate human cardiogenesis have
provided a powerful tool for unveiling human cardiac development, studying cardiovascular …

To define the multi-cellular epigenomic and transcriptional landscape of cardiac cellular
development, we generated single-cell chromatin accessibility maps of human fetal heart …

Single-cell RNA sequencing (scRNA-seq) technology is a powerful, rapidly developing tool
for characterizing individual cells and elucidating biological mechanisms at the cellular …

Re-activating quiescent adult epicardium represents a potential therapeutic approach for
human cardiac regeneration. However, the exact molecular differences between inactive …

Aims Coronary vasculature formation is a critical event during cardiac development,
essential for heart function throughout perinatal and adult life. However, current …

The immune and fibrotic responses have evolved to work in tandem to respond to pathogen
clearance and promote tissue repair. However, excessive immune and fibrotic responses …

Implementing Single-cell RNA sequencing (scRNA-seq) has significantly enhanced our
comprehension of cardiovascular diseases (CVDs), providing new opportunities to …

Endothelial cells (ECs) constitute the inner lining of vascular beds in mammals and are
crucial for homeostatic regulation of blood vessel physiology, but also play a key role in …

Fulminant myocarditis (FM) is a life-threatening inflammatory disease. However, the
mechanisms underlying its acute onset are unknown. By dynamic cardiac function …