Recent evidence suggests that neurotrophic factors that promote the survival or
differentiation of developing neurons may also protect mature neurons from neuronal …

Intraventricular administration of nerve growth factor (NGF) in rats has been shown to reduce
age-related atrophy of central cholinergic neurons and the accompanying memory …

Expression of p75 neurotrophin receptor and survival of medium-sized spiny projection
neurons and cholinergic interneurons in the rat striatum were studied using …

The survival of different neuron types and the expression of the p75 neurotrophin receptor
(p75NTR) after focal cerebral ischemia were studied in the mouse striatum using …

While the therapeutic potential of neurotrophic factors has been well-recognized for over two
decades, attempts to translate that potential to the clinic have been disappointing, largely …

After injury, the striatum displays several morphologic responses that may play a role in both
regenerative and degenerative events. One such response is the de novo expression of the …

In many neurological disorders, specific neuronal populations are selectively vulnerable.
This is especially true for patients with Alzheimer's disease (AD). A consistent and early …

The selective vulnerability of specific neuronal populations in the brain is a feature of various
neurological disorders, including Alzheimer's disease (AD). A consistent and early …