Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

The nodes of Ranvier have clustered Na+ and K+ channels necessary for rapid and efficient
axonal action potential conduction. However, detailed mechanisms of channel clustering …

Thousands of mammalian messenger RNAs are under selective pressure to maintain 7-
nucleotide sites matching microRNAs (miRNAs). We found that these conserved targets are …

A perineuronal net (PNN) is a layer of lattice‐like matrix which enwraps the surface of the
soma and dendrites, and in some cases the axon initial segments, in sub‐populations of …

Perineuronal nets (PNNs) are reticular structures that surround the cell body of many
neurones, and extend along their dendrites. They are considered to be a specialized …

Efficient and rapid propagation of action potentials in myelinated axons depends on the
molecular specialization of the nodes of Ranvier. The nodal region is organized into several …

Chondroitin sulfate proteoglycans (CSPGs) consist of a core protein and glycosaminoglycan
(GAG) chains. There is enormous structural diversity among CSPGs due to variation in the …

The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin
sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins …

We developed a method to extract differentially chondroitin sulfate proteoglycans (CSPGs)
that are diffusely present in the central nervous system (CNS) matrix and CSPGs that are …

Background The extracellular matrix (ECM) of the brain is rich in glycosaminoglycans such
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …