Post‐translational modifications of histones: Mechanisms, biological functions, and therapeutic targets
R Liu, J Wu, H Guo, W Yao, S Li, Y Lu, Y Jia… - MedComm, 2023 - Wiley Online Library
Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …
translation, its amino tail undergoes various modifications, such as methylation, acetylation …
P21 activated kinase signaling in cancer
CK Rane, A Minden - Seminars in cancer biology, 2019 - Elsevier
Abstract The p21 Activated Kinases (PAKs) are a family of serine threonine kinases, that
consist of 6 members, PAKs 1–6, which are positioned at an intersection of multiple …
consist of 6 members, PAKs 1–6, which are positioned at an intersection of multiple …
Role of silymarin in cancer treatment: facts, hypotheses, and questions
The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …
Apigenin as tumor suppressor in cancers: Biotherapeutic activity, nanodelivery, and mechanisms with emphasis on pancreatic cancer
Pancreatic cancer is the most lethal malignancy of the gastrointestinal tract. Due to its
propensity for early local and distant spread, affected patients possess extremely poor …
propensity for early local and distant spread, affected patients possess extremely poor …
Molecular and cellular mechanisms of chemoresistance in pancreatic cancer
A Adamska, O Elaskalani, A Emmanouilidi… - Advances in biological …, 2018 - Elsevier
Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most chemoresistant
cancers, and current therapies targeting cancer-associated molecular pathways have not …
cancers, and current therapies targeting cancer-associated molecular pathways have not …
Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy
A Borah, S Raveendran, A Rochani, T Maekawa… - Oncogenesis, 2015 - nature.com
Extensive cancer research in the past few decades has identified the existence of a rare
subpopulation of stem cells in the grove of cancer cells. These cells are known as the cancer …
subpopulation of stem cells in the grove of cancer cells. These cells are known as the cancer …
Hyaluronic acid-conjugated polyamidoamine dendrimers for targeted delivery of 3, 4-difluorobenzylidene curcumin to CD44 overexpressing pancreatic cancer cells
The current study was aimed to develop a targeted dendrimer formulation of 3, 4-
difluorobenzylidene curcumin (CDF) and evaluate its potential in CD44 targeted therapy for …
difluorobenzylidene curcumin (CDF) and evaluate its potential in CD44 targeted therapy for …
[HTML][HTML] UTMD-promoted co-delivery of gemcitabine and miR-21 inhibitor by dendrimer-entrapped gold nanoparticles for pancreatic cancer therapy
L Lin, Y Fan, F Gao, L Jin, D Li, W Sun, F Li, P Qin… - Theranostics, 2018 - ncbi.nlm.nih.gov
Conventional chemotherapy of pancreatic cancer (PaCa) suffers the problems of low drug
permeability and inherent or acquired drug resistance. Development of new strategies for …
permeability and inherent or acquired drug resistance. Development of new strategies for …
The role of CD44 in cancer chemoresistance: A concise review
CD44 is a cell surface adhesion molecule, which is overexpressed on cancer stem cells.
The interaction of CD44 with hyaluronan is responsible for tumor development, metastasis …
The interaction of CD44 with hyaluronan is responsible for tumor development, metastasis …
Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) exhibits severe hypoxia, which is associated
with chemoresistance and worse patient outcome. It has been reported that hypoxia induces …
with chemoresistance and worse patient outcome. It has been reported that hypoxia induces …