[HTML][HTML] Multitarget Pharmacology of Sulfur–Nitrogen Heterocycles: Anticancer and Antioxidant Perspectives
A Drakontaeidi, I Papanotas, E Pontiki - Antioxidants, 2024 - mdpi.com
Cancer and oxidative stress are interrelated, with reactive oxygen species (ROS) playing
crucial roles in physiological processes and oncogenesis. Excessive ROS levels can induce …
crucial roles in physiological processes and oncogenesis. Excessive ROS levels can induce …
Green synthesis and biological evaluation of 6-substituted-2-(2-hydroxy/methoxy phenyl) benzothiazole derivatives as potential antioxidant, antibacterial and …
L Racané, L Ptiček, G Fajdetić, V Tralić-Kulenović… - Bioorganic …, 2020 - Elsevier
We present a new efficient green synthetic protocol for introduction of substituents to the C-6
position of 2-arylbenzothiazole nuclei. Newly synthesized compounds were designed to …
position of 2-arylbenzothiazole nuclei. Newly synthesized compounds were designed to …
Novel amidino substituted benzimidazole and benzothiazole benzo [b] thieno-2-carboxamides exert strong antiproliferative and DNA binding properties
Within this manuscript design, synthesis of novel 2-imidazolinyl substituted benzo [b] thieno-
2-carboxamides bearing either benzimidazole or benzothiazole subunit and biological …
2-carboxamides bearing either benzimidazole or benzothiazole subunit and biological …
Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose
L Racané, L Ptiček, S Kostrun… - Journal of medicinal …, 2023 - ACS Publications
We designed and synthesized a series of symmetric bis-6-amidino-benzothiazole
derivatives with aliphatic central units and evaluated their efficacy against bloodstream …
derivatives with aliphatic central units and evaluated their efficacy against bloodstream …
Preclinical in vitro screening of newly synthesised amidino substituted benzimidazoles and benzothiazoles
Newly synthesised benzimidazole/benzotiazole derivatives bearing amidino, namely 3, 4, 5,
6-tetrahydropyrimidin-1-ium chloride, substituents have been evaluated for their potential …
6-tetrahydropyrimidin-1-ium chloride, substituents have been evaluated for their potential …
Biological activity of newly synthesized benzimidazole and benzothizole 2, 5-disubstituted furane derivatives
Newly designed and synthesized cyano, amidino and acrylonitrile 2, 5-disubstituted furane
derivatives with either benzimidazole/benzothiazole nuclei have been evaluated for …
derivatives with either benzimidazole/benzothiazole nuclei have been evaluated for …
Palladium (II) and platinum (II) complexes of derivatives of 2-(4′-aminophenyl) benzothiazole as potential anticancer agents
The synthesis, structural characterization and in vitro biological evaluation of two 2-(4′-
aminophenyl) benzothiazole based ligands and their corresponding Pd (II) and Pt (II) …
aminophenyl) benzothiazole based ligands and their corresponding Pd (II) and Pt (II) …
Experimental and computational study of the antioxidative potential of novel nitro and amino substituted benzimidazole/benzothiazole-2-carboxamides with …
We present the synthesis of a range of benzimidazole/benzothiazole-2-carboxamides with a
variable number of methoxy and hydroxy groups, substituted with nitro, amino, or amino …
variable number of methoxy and hydroxy groups, substituted with nitro, amino, or amino …
Amidino substituted 2-aminophenols: Biologically important building blocks for the amidino-functionalization of 2-substituted benzoxazoles
Unlike the closely related and widely investigated amidino-substituted benzimidazoles and
benzothiazoles with a range of demonstrated biological activities, the matching benzoxazole …
benzothiazoles with a range of demonstrated biological activities, the matching benzoxazole …
Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles
L Racané, V Rep, S Kraljević Pavelić… - Journal of enzyme …, 2021 - Taylor & Francis
A series of 6-amidinobenzothiazoles, linked via phenoxymethylene or directly to the 1, 2, 3-
triazole ring with ap-substituted phenyl or benzyl moiety, were synthesised and evaluated in …
triazole ring with ap-substituted phenyl or benzyl moiety, were synthesised and evaluated in …