Oocyte activation deficiency: a role for an oocyte contribution?

M Yeste, C Jones, SN Amdani, S Patel… - Human reproduction …, 2016 - academic.oup.com
BACKGROUND Infertility affects between 10 and 16% of couples worldwide. Twenty to 30%
of cases of infertility are due to a male factor, 20–35% to a female factor, and 25–40% are …

PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS

JL Dahlin, JWM Nissink, JM Strasser… - Journal of medicinal …, 2015 - ACS Publications
Significant resources in early drug discovery are spent unknowingly pursuing artifacts and
promiscuous bioactive compounds, while understanding the chemical basis for these …

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

JM Park, CH Jung, M Seo, NM Otto, D Grunwald… - Autophagy, 2016 - Taylor & Francis
abstract ULK1 (unc-51 like autophagy activating kinase 1), the key mediator of MTORC1
signaling to autophagy, regulates early stages of autophagosome formation in response to …

Inactivation of virus in solution by cold atmospheric pressure plasma: identification of chemical inactivation pathways

HA Aboubakr, U Gangal, MM Youssef… - Journal of Physics D …, 2016 - iopscience.iop.org
Cold atmospheric pressure plasma (CAP) inactivates bacteria and virus through in situ
production of reactive oxygen and nitrogen species (RONS). While the bactericidal and …

[HTML][HTML] Genome-wide association study on milk production and somatic cell score for Thai dairy cattle using weighted single-step approach with random regression …

S Buaban, K Lengnudum, W Boonkum… - Journal of Dairy …, 2022 - Elsevier
ABSTRACTS Genome-wide association studies are a powerful tool to identify genomic
regions and variants associated with phenotypes. However, only limited mutual confirmation …

Identification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells

Y Jing, Z Ni, J Wu, LA Higgins, TW Markowski… - PloS one, 2015 - journals.plos.org
CD16a and CD16b are IgG Fc receptors expressed by human natural killer (NK) cells and
neutrophils, respectively. Both CD16 isoforms undergo a rapid down-regulation in …

Identification and Characterization of the SnTox6-Snn6 Interaction in the Parastagonospora nodorum–Wheat Pathosystem

Y Gao, JD Faris, Z Liu, YM Kim… - Molecular Plant …, 2015 - Am Phytopath Society
Parastagonospora nodorum is a necrotrophic fungal pathogen that causes Septoria
nodorum blotch (SNB)(formerly Stagonospora nodorum blotch) on wheat. P. nodorum …

Participation of selenoproteins localized in the ER in the processes occurring in this organelle and in the regulation of carcinogenesis-associated processes

EG Varlamova - Journal of Trace Elements in Medicine and Biology, 2018 - Elsevier
The functions performed by the ER are diverse: synthesis of steroid hormones, synthesis of
proteins for the plasma membrane, lysosomes, as well as proteins meant for exocytosis …

RBM17 interacts with U2SURP and CHERP to regulate expression and splicing of RNA-processing proteins

A De Maio, HK Yalamanchili, CJ Adamski… - Cell reports, 2018 - cell.com
RNA splicing entails the coordinated interaction of more than 150 proteins in the
spliceosome, one of the most complex of the cell's molecular machines. We previously …

mRNA 3′-UTR shortening is a molecular signature of mTORC1 activation

JW Chang, W Zhang, HS Yeh, EP De Jong… - Nature …, 2015 - nature.com
Mammalian target of rapamycin (mTOR) enhances translation from a subset of messenger
RNAs containing distinct 5′-untranslated region (UTR) sequence features. Here we identify …