Along with advanced age and apolipoprotein E (APOE)-4 genotype, female sex is a major
risk factor for developing late-onset Alzheimer's disease (AD). Considering that AD …

Menopause, the permanent cessation of the menstrual cycle, marks the end of a woman's
reproductive lifespan. In addition to changes in sex hormone levels associated with …

Premature ovarian insufficiency (POI) is a condition that arises from dysfunction or early
depletion of the ovarian follicle pool accompanied by an earlier-than-normal loss of fertility in …

This narrative review discusses the current understanding, knowledge gaps and challenges
in expanding our knowledge of the association between menopause and the reproductive …

As the rate of obesity increases globally, so does the incidence of other non-communicable
diseases such as diabetes, cardiovascular disease, cancer, osteoporosis, osteoarthritis, and …

Increased life expectancy means that women are now in a hypoestrogenic state for
approximately one-third of their lives. Overall health and specifically bone health during this …

Background Exposure to metals and metal mixtures may influence ovarian aging. However,
epidemiologic evidence of their potential impact is lacking. Objective We prospectively …

This study aimed to investigate the association between diet and the risk of breast,
endometrial and ovarian cancer in the UK Women's Cohort Study. A total of 35 372 women …

Ovarian dysfunction increases risk for chronic diseases of aging including cardiovascular
disease, depression, cognitive impairment, as well as bone and muscle loss which promote …

Background Diet has been suggested to play a role in determining the age at natural
menopause; however, the evidence is inconsistent. Objective We systematically reviewed …