Mutations in methyl CpG binding protein 2 (MeCP2) are the major cause of Rett syndrome
(RTT), a rare neurodevelopmental disorder with a notable period of developmental …

Heredity has a major role in autism spectrum disorder (ASD), yet underlying causal genetic
variants have been defined only in a fairly small subset of cases. The enormous genetic …

The mechanisms that confer cognitive resilience to Alzheimer's Disease (AD) are not fully
understood. Here, we describe a neural circuit mechanism underlying this resilience in a …

The decline of brain function during aging is associated with epigenetic changes, including
DNA methylation. Lifestyle interventions can improve brain function during aging, but their …

RNA splicing is the enzymatic process by which non-protein coding sequences are removed
from RNA to produce mature protein-coding mRNA. Splicing is thereby a major mediator of …

MeCP2 protein, encoded by the MECP2 gene, binds to DNA and affects transcription.
Outside of this activity the true range of MeCP2 function is still not entirely clear. As MECP2 …

Using unsupervised metabolomics, we defined the complex metabolic conditions in the
cortex of a mouse model of Rett syndrome (RTT). RTT, which represents a cause of mental …

Rett syndrome (RTT) is an extremely invalidating, cureless, developmental disorder, and it is
considered one of the leading causes of intellectual disability in female individuals. The vast …

Noncoding RNAs play regulatory roles in physiopathology, but their involvement in
neurodevelopmental diseases is poorly understood. Rett syndrome is a severe, progressive …

Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized
by social deficits and restrictive and/or repetitive behaviors. The breadth of ASD symptoms is …