From loci to biology: functional genomics of genome-wide association for coronary disease
Genome-wide association studies have provided a rich collection of≈ 58 coronary artery
disease (CAD) loci that suggest the existence of previously unsuspected new biology …
disease (CAD) loci that suggest the existence of previously unsuspected new biology …
Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions
Background: Common diseases such as coronary heart disease (CHD) are complex in
etiology. The interaction of genetic susceptibility with lifestyle factors may play a prominent …
etiology. The interaction of genetic susceptibility with lifestyle factors may play a prominent …
Large‐scale gene‐centric analysis identifies polymorphisms for resistant hypertension
Background Resistant hypertension (RHTN), defined by lack of blood pressure (BP) control
despite treatment with at least 3 antihypertensive drugs, increases cardiovascular risk …
despite treatment with at least 3 antihypertensive drugs, increases cardiovascular risk …
SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis
MJ Flister, MJ Hoffman, A Lemke… - Circulation …, 2015 - Am Heart Assoc
Background—Genome-wide association studies are powerful tools for nominating
pathogenic variants, but offer little insight as to how candidate genes affect disease …
pathogenic variants, but offer little insight as to how candidate genes affect disease …