The rising global prevalence of obesity, metabolic syndrome, and type 2 diabetes has driven
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …

Fibroblast growth factor 21 (FGF21) is a peptide hormone that is synthesized by several
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …

It has been more than a dozen years since FGF21 burst on the metabolism field in a paper
showing that its pharmacologic administration caused weight loss and improved insulin …

Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …

Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and
metabolic homeostasis. During evolution, the ancestor FGF expands into multiple members …

The endocrine FGF21 was discovered as a novel metabolic regulator in 2005 with new
functions bifurcating from the canonic heparin-binding FGFs that directly promote cell …

The metabolic stress hormone FGF21 is highly expressed in exocrine pancreas, where its
levels are increased by refeeding and chemically induced pancreatitis. However, its function …

As an endocrine hormone, fibroblast growth factor 21 (FGF21) plays a crucial role in
regulating lipid, glucose, and energy metabolism. Endogenous FGF21 is generated by …

Fibroblast growth factor 21 (FGF21) is an important endocrine metabolic regulator
expressed in multiple tissues including liver and adipose tissue. Although highest levels of …

Fibroblast growth factor (FGF) 21 belongs to a hormone‐like subgroup within the FGF
superfamily. The members of this subfamily, FGF 19, FGF 21 and FGF 23, are characterized …