Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines

R Sartorius, M Trovato, R Manco, L D'Apice… - npj Vaccines, 2021 - nature.com
Toll-like receptors (TLRs) are transmembrane proteins belonging to the family of pattern-
recognition receptors. They function as sensors of invading pathogens through recognition …

Recent advances in the understanding of enterovirus A71 infection: a focus on neuropathogenesis

HK Tee, MI Zainol, IC Sam, YF Chan - Expert Review of Anti …, 2021 - Taylor & Francis
Introduction: Hand, foot, and mouth disease caused by enterovirus A71 (EV-A71) is more
frequently associated with neurological complications and deaths compared to other …

EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production

Z Luo, R Su, W Wang, Y Liang, X Zeng… - PLoS …, 2019 - journals.plos.org
As a neurotropic virus, human Enterovirus 71 (EV71) infection causes hand-foot-and-mouth
disease (HFMD) and may develop severe neurological disorders in infants. Toll-like receptor …

Exosomes cloak the virion to transmit Enterovirus 71 non-lytically

J Gu, J Wu, D Fang, Y Qiu, X Zou, X Jia, Y Yin, L Shen… - Virulence, 2020 - Taylor & Francis
ABSTRACT Enterovirus 71 (EV71) is a non-enveloped virus and it can be released from
host cells through a traditional cytolytic manner. Now, we showed EV71 could be spread …

Enterovirus 71 non-structural protein 3A hijacks vacuolar protein sorting 25 to boost exosome biogenesis to facilitate viral replication

Z Ruan, Y Liang, Z Chen, J Yin, C Li, P Pan… - Frontiers in …, 2022 - frontiersin.org
Human enterovirus 71 (EV71) is one of the major agents of the hand, foot, and mouth
disease (HFMD), and occasionally causes severe neurological complications. There is …

The TLR3/IRF1/Type III IFN axis facilitates antiviral responses against enterovirus infections in the intestine

R Su, MA Shereen, X Zeng, Y Liang, W Li, Z Ruan, Y Li… - MBio, 2020 - Am Soc Microbiol
Enteroviruses infect gastrointestinal epithelium cells, cause multiple human diseases, and
present public health risks worldwide. However, the mechanisms underlying host immune …

[HTML][HTML] Prunetin inhibits lipopolysaccharide-induced inflammatory cytokine production and MUC5AC expression by inactivating the TLR4/MyD88 pathway in human …

H Hu, H Li - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Allergic rhinitis (AR) is a chronic upper respiratory disorder characterized by inflammation of
the nasal mucosa. Prunetin is an O-methylated isoflavone, which has been found to possess …

Interplays between Enterovirus A71 and the innate immune system

KR Chen, P Ling - Journal of biomedical science, 2019 - Springer
Abstract Enterovirus A71 (EV-A71) is a growing threat to public health, particularly in the
Asia-Pacific region. EV-A71 infection is most prevalent in infants and children and causes a …

Antiviral and inflammatory cellular signaling associated with enterovirus 71 infection

Y Jin, R Zhang, W Wu, G Duan - Viruses, 2018 - mdpi.com
Enterovirus 71 (EV71) infection has become a major threat to global public health,
especially in infants and young children. Epidemiological studies have indicated that EV71 …

Activation of host cellular signaling and mechanism of enterovirus 71 viral proteins associated with hand, foot and mouth disease

SK Swain, S Panda, BP Sahu, R Sarangi - Viruses, 2022 - mdpi.com
Enteroviruses are members of the Picornaviridae family consisting of human enterovirus
groups A, B, C, and D as well as nonhuman enteroviruses. Human enterovirus type 71 …