The discovery of nitric oxide (NO) as a crucial endothe-lium-derived molecule for vascular
relaxation and the recognition of the endothelium as more than a passive interface between …

Atherosclerosis is one of the main complications of diabetes involving multiple causative
factors. Dysfunction of the vascular endothelium is a hallmark of most conditions that are …

As the major regulator of vascular homeostasis, the endothelium exerts a number of
vasoprotective effects, such as vasodilation, suppression of smooth muscle cell growth, and …

In normal vascular physiology, NO plays a key role to maintain the vascular wall in a
quiescent state by inhibition of inflammation, cellular proliferation, and thrombosis. This is in …

Coronary atherosclerosis is by far the most frequent cause of ischemic heart disease, and
plaque disruption with superimposed thrombosis is the main cause of the acute coronary …

PART I THE ENDOTHELIUM has long been viewed as an inert cellophane-like membrane
that lines the circulatory system with its primary essential function being the maintenance of …

The endothelium exerts multiple actions involving regulation of vascular permeability and
tone, coagulation and fibrinolysis, inflammatory and immunological reactions and cell …

Defining new approaches for the prevention and treatment of atherosclerosis is an important
priority. Recently, measurement of endothelial function in patients has emerged as a useful …

Background Endothelial function is impaired in coronary artery disease and may contribute
to its clinical manifestations. Increased oxidative stress has been linked to impaired …

Background—Endothelial vasodilator dysfunction is a characteristic feature of patients at risk
for coronary atherosclerosis. Therefore, we prospectively investigated whether coronary …