This review describes unique neuromodulatory influences on working memory prefrontal
cortical (PFC) circuits that coordinate cognitive strength with arousal state. Working memory …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

▪ Abstract Hyperpolarization-activated cation currents, termed If, Ih, or Iq, were initially
discovered in heart and nerve cells over 20 years ago. These currents contribute to a wide …

Background Psychiatric disorders such as schizophrenia are worsened by stress, and
working memory deficits are often a central feature of illness. Working memory is mediated …

A chronic compression of the DRG (CCD) produces cutaneous hyperalgesia and an
enhanced excitability of neuronal somata in the compressed ganglion. The …

The sympathetic nervous system increases heart rate by activating β adrenergic receptors
and increasing cAMP levels in myocytes in the sinoatrial node. The molecular basis for this …

The working memory circuits of the primate dorsolateral prefrontal cortex (dlPFC) are
modulated in a unique manner, often opposite to the molecular mechanisms needed for …

Recent results indicate that phosphoinositides, including phosphatidylinositol 4, 5-
bisphosphate (PI (4, 5) P 2), directly enhance the opening of hyperpolarization-activated …

The regulation of intracellular calcium by the endoplasmic reticulum (ER) plays a critical role
in neuronal function. While the consequences associated with depleting calcium from the …

While chronic stress increases hyperpolarization-activated current (I h) in dorsal
hippocampal CA1 neurons, the underlying molecular mechanisms are entirely unknown …