Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations
Candidate phyla radiation (CPR) bacteria and DPANN (an acronym of the names of the first
included phyla) archaea are massive radiations of organisms that are widely distributed …
included phyla) archaea are massive radiations of organisms that are widely distributed …
Engineering tRNAs for the Ribosomal Translation of Non-proteinogenic Monomers
M Sigal, S Matsumoto, A Beattie, T Katoh… - Chemical …, 2024 - ACS Publications
Ribosome-dependent protein biosynthesis is an essential cellular process mediated by
transfer RNAs (tRNAs). Generally, ribosomally synthesized proteins are limited to the 22 …
transfer RNAs (tRNAs). Generally, ribosomally synthesized proteins are limited to the 22 …
tRNA shape is an identity element for an archaeal pyrrolysyl-tRNA synthetase from the human gut
Protein translation is orchestrated through tRNA aminoacylation and ribosomal elongation.
Among the highly conserved structure of tRNAs, they have distinguishing features which …
Among the highly conserved structure of tRNAs, they have distinguishing features which …
Modern diversification of the amino acid repertoire driven by oxygen
All extant life employs the same 20 amino acids for protein biosynthesis. Studies on the
number of amino acids necessary to produce a foldable and catalytically active polypeptide …
number of amino acids necessary to produce a foldable and catalytically active polypeptide …
Evolution of life on earth: tRNA, aminoacyl-tRNA synthetases and the genetic code
L Lei, ZF Burton - Life, 2020 - mdpi.com
Life on Earth and the genetic code evolved around tRNA and the tRNA anticodon. We posit
that the genetic code initially evolved to synthesize polyglycine as a cross-linking agent to …
that the genetic code initially evolved to synthesize polyglycine as a cross-linking agent to …
Research Progress of the Biosynthesis of Natural Bio-Antibacterial Agent Pulcherriminic Acid in Bacillus
S Yuan, X Yong, T Zhao, Y Li, J Liu - Molecules, 2020 - mdpi.com
Pulcherriminic acid is a cyclic dipeptide found mainly in Bacillus and yeast. Due to the ability
of pulcherriminic acid to chelate Fe3+ to produce reddish brown pulcherrimin …
of pulcherriminic acid to chelate Fe3+ to produce reddish brown pulcherrimin …
[HTML][HTML] Natural and engineered cyclodipeptides: Biosynthesis, chemical diversity, and engineering strategies for diversification and high-yield bioproduction.
WS Widodo, S Billerbeck - Engineering Microbiology, 2023 - Elsevier
Cyclodipeptides are diverse chemical scaffolds that show a broad range of bioactivities
relevant for medicine, agriculture, chemical catalysis, and material sciences …
relevant for medicine, agriculture, chemical catalysis, and material sciences …
Diversification of aminoacyl-tRNA synthetase activities via genomic duplication
Intricate evolutionary events enabled the emergence of the full set of aminoacyl-tRNA
synthetase (aaRS) families that define the genetic code. The diversification of aaRSs has …
synthetase (aaRS) families that define the genetic code. The diversification of aaRSs has …
The tRNA discriminator base defines the mutual orthogonality of two distinct pyrrolysyl-tRNA synthetase/tRNAPyl pairs in the same organism
H Zhang, X Gong, Q Zhao, T Mukai… - Nucleic Acids …, 2022 - academic.oup.com
Site-specific incorporation of distinct non-canonical amino acids into proteins via genetic
code expansion requires mutually orthogonal aminoacyl-tRNA synthetase/tRNA pairs …
code expansion requires mutually orthogonal aminoacyl-tRNA synthetase/tRNA pairs …
Engineering aminoacyl-tRNA synthetases for use in synthetic biology
Within the broad field of synthetic biology, genetic code expansion (GCE) techniques enable
creation of proteins with an expanded set of amino acids. This may be invaluable for …
creation of proteins with an expanded set of amino acids. This may be invaluable for …