Natural products continue to provide a diverse and unique source of bioactive lead
compounds for drug discovery, but maintaining their continued eminence as source …

Marine organisms have proven to be rich sources of unique alkaloids. In earlier surveys we
comprehensively reviewed several intriguing groups of marine alkaloids, including the …

Although toxicants may initiate cell damage or stress, the cellular proteins that are involved
in control of cell cycle and apoptosis are the final arbiters of cell fate. The biochemical …

Inhibition of the Chk1 kinase by small molecules is of great therapeutic interest for oncology
and in understanding the cellular regulation of the G2/M checkpoint. We report how …

This article offers an overview on the historical facts and the recent state of art of Chemistry
of Natural Products which, in the course of 25 years of SBQ, have led to the present …

Cell-cycle dysregulation is a hallmark of tumor cells. The ability of normal cells to undergo
cell-cycle arrest after damage to DNA is crucial for the maintenance of genomic integrity. The …

Many conventional anticancer treatments kill cells irrespective of whether they are normal or
cancerous, so patients suffer from adverse side effects due to the loss of healthy cells …

Chemical genetics is the study of gene-product function in a cellular or organismal context
using exogenous ligands. In this approach, small molecules that bind directly to proteins are …

In the last decade, the discovery and cloning of the cyclin-dependent kinases (cdks), key
regulators of cell cycle progression, have led to the identification of novel modulators of cdk …

Through targeted homologous recombination, we developed a panel of matched colorectal
cancer cell lines that differ only with respect to their endogenous TP53 status. We then used …