Anti-inflammatory and active biological properties of the plant-derived bioactive compounds luteolin and luteolin 7-glucoside

S Caporali, A De Stefano, C Calabrese, A Giovannelli… - Nutrients, 2022 - mdpi.com
Flavonoids are interesting molecules synthetized by plants. They can be found abundantly
in seeds and fruits, determining the color, flavor, and other organoleptic characteristics, as …

The hallmarks of flavonoids in cancer

LGS Ponte, ICB Pavan, MCS Mancini, LGS da Silva… - Molecules, 2021 - mdpi.com
Flavonoids represent an important group of bioactive compounds derived from plant-based
foods and beverages with known biological activity in cells. From the modulation of …

Caution,“normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021

O Golubnitschaja, A Liskova, L Koklesova, M Samec… - EPMA Journal, 2021 - Springer
An increasing interest in a healthy lifestyle raises questions about optimal body weight.
Evidently, it should be clearly discriminated between the standardised “normal” body weight …

All around suboptimal health—a joint position paper of the Suboptimal Health Study Consortium and European Association for Predictive, Preventive and …

W Wang, Y Yan, Z Guo, H Hou, M Garcia, X Tan… - EPMA Journal, 2021 - Springer
First two decades of the twenty-first century are characterised by epidemics of non-
communicable diseases such as many hundreds of millions of patients diagnosed with …

Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine

X Zhan, J Li, Y Guo, O Golubnitschaja - EPMA Journal, 2021 - Springer
Over the last two decades, a large number of non-communicable/chronic disorders reached
an epidemic level on a global scale such as diabetes mellitus type 2, cardio-vascular …

Royal jelly acid suppresses hepatocellular carcinoma tumorigenicity by inhibiting H3 histone lactylation at H3K9la and H3K14la sites

H Xu, L Li, S Wang, Z Wang, L Qu, C Wang, K Xu - Phytomedicine, 2023 - Elsevier
Background and purpose Human hepatocellular carcinoma (HCC) features include
enhanced glycolysis and elevated lactate concentrations. Accumulation of lactate during …

Flavonoids as an effective sensitizer for anti-cancer therapy: Insights into multi-faceted mechanisms and applicability towards individualized patient profiles

A Liskova, M Samec, L Koklesova, A Brockmueller… - Epma Journal, 2021 - Springer
Cost-efficacy of currently applied treatments is an issue in overall cancer management
challenging healthcare and causing tremendous economic burden to societies around the …

Elucidating role of reactive oxygen species (ROS) in cisplatin chemotherapy: a focus on molecular pathways and possible therapeutic strategies

S Mirzaei, K Hushmandi, A Zabolian, H Saleki… - Molecules, 2021 - mdpi.com
The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective
treatment of cancer patients, it is of great importance to reveal the molecular pathways and …

Mitochondrial health quality control: measurements and interpretation in the framework of predictive, preventive, and personalized medicine

L Koklesova, A Mazurakova, M Samec, E Kudela… - EPMA Journal, 2022 - Springer
Mitochondria are the “gatekeeper” in a wide range of cellular functions, signaling events, cell
homeostasis, proliferation, and apoptosis. Consequently, mitochondrial injury is linked to …

Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care

A Mazurakova, L Koklesova, M Samec, E Kudela… - EPMA Journal, 2022 - Springer
Breast cancer incidence is actually the highest one among all cancers. Overall breast cancer
management is associated with challenges considering risk assessment and predictive …