Significance: Over-nutrition and sedentary lifestyle has led to a worldwide increase in
obesity, insulin resistance, and type 2 diabetes (T2D) associated with an increased risk of …

Endurance exercise training is known to promote beneficial adaptations to numerous tissues
including the heart. Indeed, endurance exercise training results in a cardioprotective …

Aims Although the cardiovascular benefits of exercise are well known, exercise induced
effects and mechanisms in prevention of cardiomyopathy are less clear during obesity …

Exercise has an effect on the reduction of myocardial fibrosis in diabetic rats as previously
reported, in which oxidative stress and the TGF-β1/Smad signaling pathway may play key …

Controversy exists on the benefits versus harms of n-6 polyunsaturated fatty acids (n-6
PUFA). Although n-6 PUFA demonstrates anti-atherosclerotic properties, survival following …

PGC-1α, a transcriptional coactivator, controls inflammation and mitochondrial gene
expression in insulin-sensitive tissues following exercise intervention. However, attributing …

The number of geriatrics with an advanced age is rising worldwide, with attendant
cardiovascular disorders, characterized by elevated oxidative stress. Such oxidative stress is …

Mitochondrial dysfunction has a significant role in the development of diabetic
cardiomyopathy. Mitochondrial oxidant stress has been accepted as the singular cause of …

Background and Purpose The effect of antioxidants on ageing type 2 diabetic (T 2 D) hearts
during exercise is unclear. We hypothesized that GSH therapy during exercise reduces …

A certain dosage of cyclophosphamide (CYP) in clinical applications contributes to severe
cardiotoxicity. Herein, this study explored the impact of adipose-derived mesenchymal stem …