Recent progress on vascular endothelial growth factor receptor inhibitors with dual targeting capabilities for tumor therapy
Y Liu, Y Li, Y Wang, C Lin, D Zhang, J Chen… - Journal of Hematology & …, 2022 - Springer
Vascular endothelial growth factor receptors (VEGFRs) are a family of receptor protein
tyrosine kinases that play an important role in the regulation of tumor-induced angiogenesis …
tyrosine kinases that play an important role in the regulation of tumor-induced angiogenesis …
Recent development of multi-target VEGFR-2 inhibitors for the cancer therapy
XJ Liu, HC Zhao, SJ Hou, HJ Zhang, L Cheng… - Bioorganic …, 2023 - Elsevier
Vascular epidermal growth factor receptor-2 (VEGFR-2), as an important tyrosine
transmembrane protein, plays an important role in regulating endothelial cell proliferation …
transmembrane protein, plays an important role in regulating endothelial cell proliferation …
Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers
FG Abdulrahman, HS Abulkhair, HS El Saeed… - Bioorganic …, 2024 - Elsevier
As regards to the structural analysis and optimization of diverse potential EGFR inhibitors,
two series of imidazolyl-2-cyanoprop-2-enimidothioates and ethyl …
two series of imidazolyl-2-cyanoprop-2-enimidothioates and ethyl …
Epidermal growth factor receptor dual-target inhibitors as a novel therapy for cancer: A review
C Wang, Y Zhang, T Zhang, J Xu, S Yan, B Liang… - International Journal of …, 2023 - Elsevier
Overexpression of the epidermal growth factor receptor (EGFR) has been linked to several
human cancers, including esophageal cancer, pancreatic cancer, anal cancer, breast …
human cancers, including esophageal cancer, pancreatic cancer, anal cancer, breast …
Novel imidazolium-thiohydantoin hybrids and their Mn (III) complexes for antimicrobial and anti-liver cancer applications
LA Ismail, R Zakaria, EM Hassan, MY Alfaifi, AA Shati… - RSC …, 2022 - pubs.rsc.org
We present the effective synthesis and structural characterization of three novel imidazolium-
thiohydantoin ligands (IMTHs, 5a–c) and their Mn (III) complexes (Mn (III) IMTHs, 6a–c) in …
thiohydantoin ligands (IMTHs, 5a–c) and their Mn (III) complexes (Mn (III) IMTHs, 6a–c) in …
Recent Advances and Future Directions on Small Molecule VEGFR Inhibitors in Oncological Conditions
A Thakur, M Rana, A Mishra, C Kaur, CH Pan… - European Journal of …, 2024 - Elsevier
ABSTRACT “A journey of mixed emotions” is a quote that best describes the progress chart
of vascular endothelial growth factor receptor (VEGFR) inhibitors as cancer therapeutics in …
of vascular endothelial growth factor receptor (VEGFR) inhibitors as cancer therapeutics in …
Recent updates on potential of VEGFR-2 small-molecule inhibitors as anticancer agents
PJ Chaudhari, AR Nemade, AA Shirkhedkar - RSC advances, 2024 - pubs.rsc.org
The vascular endothelial growth factor receptor (VEGFR) system is the key component for
controlling angiogenesis in cancer cells. Blocking vascular endothelial growth factor …
controlling angiogenesis in cancer cells. Blocking vascular endothelial growth factor …
Design and Synthesis of New Hydantoin Acetanilide Derivatives as Anti-NSCLC Targeting EGFRL858R/T790M Mutations
Epidermal Growth Factor Receptor (EGFR), its wild type and mutations L858R/T790M, is
overexpressed in non-small cell lung cancer (NSCLC) patients and is considered an …
overexpressed in non-small cell lung cancer (NSCLC) patients and is considered an …
In vitro anti-breast cancer study of hybrid cinnamic acid derivatives bearing 2-thiohydantoin moiety
DN Binjawhar, FA Al-Salmi, MA Alghamdi… - Future Medicinal …, 2024 - Taylor & Francis
Aim: To synthesize new hybrid cinnamic acids (10a, 10b and 11) and ester derivatives (7, 8
and 9) and investigate their anti-breast cancer activities. Materials & methods: Compounds 7 …
and 9) and investigate their anti-breast cancer activities. Materials & methods: Compounds 7 …
'In silico' repurposing new inhibitors of EGFR and VEGFR-2 kinases via biophysical mechanisms
Epidermal growth factor receptor (EGFR) controls cell growth, death, and proliferation
through a variety of signaling mechanisms. The expression of vascular endothelial growth …
through a variety of signaling mechanisms. The expression of vascular endothelial growth …