Tackling sleeping sickness: Current and promising therapeutics and treatment strategies
Human African trypanosomiasis is a neglected tropical disease caused by the extracellular
protozoan parasite Trypanosoma brucei, and targeted for eradication by 2030. The COVID …
protozoan parasite Trypanosoma brucei, and targeted for eradication by 2030. The COVID …
A novel connection between Trypanosoma brucei mitochondrial proteins TbTim17 and TbTRAP1 is discovered using Biotinylation Identification (BioID)
F Soto-Gonzalez, A Tripathi, A Cooley… - Journal of Biological …, 2022 - ASBMB
The protein translocase of the mitochondrial inner membrane in Trypanosoma brucei,
TbTIM17, forms a modular complex in association with several other trypanosome-specific …
TbTIM17, forms a modular complex in association with several other trypanosome-specific …
Multiparameter ranking of carbazoles for anti-trypanosome lead discovery
The criteria for the progression of hits in the discovery of leads for human African
trypanosomiasis (HAT), a neglected disease caused by the microbial eukaryote …
trypanosomiasis (HAT), a neglected disease caused by the microbial eukaryote …
In silico analysis of the HSP90 chaperone system from the African trypanosome, Trypanosoma brucei
M Jamabo, SJ Bentley, P Macucule-Tinga… - Frontiers in Molecular …, 2022 - frontiersin.org
African trypanosomiasis is a neglected tropical disease caused by Trypanosoma brucei (T.
brucei) and spread by the tsetse fly in sub-Saharan Africa. The trypanosome relies on heat …
brucei) and spread by the tsetse fly in sub-Saharan Africa. The trypanosome relies on heat …
[HTML][HTML] Hypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome
NEU-4438 is a lead for the development of drugs against Trypanosoma brucei, which
causes human African trypanosomiasis. Optimized with phenotypic screening, targets of …
causes human African trypanosomiasis. Optimized with phenotypic screening, targets of …
[引用][C] Physiologic targets and modes of action for CBL0137, a lead for human african trypanosomiasis drug development
CE Sanz-Rodríguez, B Hoffman, PJ Guyett… - Molecular …, 2022 - ASPET