The gut microbiota and unhealthy aging: disentangling cause from consequence

EN DeJong, MG Surette, DME Bowdish - Cell Host & Microbe, 2020 - cell.com
The gut microbiota changes with age, but it is not clear to what degree these changes are
due to physiologic changes, age-associated inflammation or immunosenescence, diet …

Implications of microbe-derived ɣ-aminobutyric acid (GABA) in gut and brain barrier integrity and GABAergic signaling in Alzheimer's disease

KA Conn, EM Borsom, EK Cope - Gut microbes, 2024 - Taylor & Francis
The gut microbial ecosystem communicates bidirectionally with the brain in what is known
as the gut-microbiome-brain axis. Bidirectional signaling occurs through several pathways …

In-depth investigation of the mechanisms of Schisandra chinensis polysaccharide mitigating Alzheimer's disease rat via gut microbiota and feces metabolomics

J Fu, J Li, Y Sun, S Liu, F Song, Z Liu - International Journal of Biological …, 2023 - Elsevier
Schisandra chinensis (S. chinensis) is an herbal medicine used for the treatment of
Alzheimer's disease (AD). The purified polysaccharide fraction, namely SCP2, was …

Emerging interrelationship between the gut microbiome and cellular senescence in the context of aging and disease: perspectives and therapeutic opportunities

R Sharma - Probiotics and Antimicrobial Proteins, 2022 - Springer
The significance of diversity, composition, and functional attributes of the gut microbiota in
shaping human health is well recognized. Studies have shown that gut microbiota is closely …

Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals

T Liwinski, MK Auer, J Schröder, I Pieknik, C Casar… - BMC medicine, 2024 - Springer
Background Limited data exists regarding gender-specific microbial alterations during
gender-affirming hormonal therapy (GAHT) in transgender individuals. This study aimed to …

Peripheral immune function and Alzheimer's disease: a living systematic review and critical appraisal

C Li, RC Stebbins, GA Noppert, CX Carney, C Liu… - Molecular …, 2024 - nature.com
Background A growing body of literature examines the relationship between peripheral
immune function and Alzheimer's Disease (AD) in human populations. Our living systematic …

Gut microbiome–immune system interaction in reptiles

R Siddiqui, SK Maciver, NA Khan - Journal of Applied …, 2022 - academic.oup.com
Reptiles are ectothermic amniotes in a world dominated by endotherms. Reptiles originated
more than 300 million years ago and they often dwell in polluted environments which may …

Xinglou Chengqi Decoction improves neurological function in experimental stroke mice as evidenced by gut microbiota analysis and network pharmacology

GAO Qiang, HAN Zhen-Yun, T Dan-Feng… - Chinese Journal of …, 2021 - Elsevier
The current study was designed to explore the brain protection mechanism of Xinglou
Chengqi Decoction (XCD) based on gut microbiota analysis and network pharmacology. A …

Bacteroides acidifaciens and its derived extracellular vesicles improve DSS-induced colitis

C Zheng, Y Zhong, J Xie, Z Wang, W Zhang… - Frontiers in …, 2023 - frontiersin.org
Introduction “Probiotic therapy” to regulate gut microbiota and intervene in intestinal
diseases such as inflammatory bowel disease (IBD) has become a research hotspot …

Accounting gut microbiota as the mediator of beneficial effects of dietary (poly) phenols on skeletal muscle in aging

A Ticinesi, A Nouvenne, N Cerundolo, A Parise… - Nutrients, 2023 - mdpi.com
Sarcopenia, the age-related loss of muscle mass and function increasing the risk of disability
and adverse outcomes in older people, is substantially influenced by dietary habits. Several …