Natural products can generally exhibit a variety of biological activities, but most show
mediocre performance in preliminary activity evaluation. Natural products often require …

The DNA topoisomerase enzymes are widely distributed throughout all spheres of life and
are necessary for cell function. Numerous antibacterial and cancer chemotherapeutic drugs …

A new series of amide derivatives derived from 1, 2, 3-triazole-benzofuran hybrids (9a-j)
have been synthesized and their structures were confirmed by using spectroscopic …

Podophyllotoxin is a naturally occurring cyclolignan isolated from rhizomes of Podophyllum
sp. In the clinic, it is used mainly as an antiviral; however, its antitumor activity is even more …

Acute lung injury (ALI) is a devastating respiratory disorder characterized by rapid alveolar
injury, uncontrolled inflammatory response, etc. Onychiol B is a cyathane diterpene …

Podophyllotoxin is an aryltetralin lignan lactone derived from different plants of
Podophyllum. It consists of five rings with four chiral centers, one trans‐lactone and one aryl …

Highlights•We described a detailed account of all the advances on podophyllotoxin
derivatives targeting tubulin from 2017 and 2022.•This review comprehensively summarized …

Cancer is a major disease threatening human health worldwide, among which non-small-
cell lung cancer (NSCLC) is the most deadly. Clinically, almost all anticancer drugs …

Abstract Hemionitis albofusca (Baker) Christenh is a plant that grows in various regions of
China. Although it is not recognized as a traditional medicine, it is often mistakenly labelled …

This study aims to develop a nanodrug delivery system containing podophyllotoxin (PTOX),
a known anticancer drug, loaded on graphene oxide (GO). The system's ability to inhibit α …