Noise permeates biology on all levels, from the most basic molecular, sub-cellular
processes to the dynamics of tissues, organs, organisms and populations. The functional …

Complex regulatory networks orchestrate most cellular processes in biological systems.
Genes in such networks are subject to expression noise, resulting in isogenic cell …

INTRODUCTION Bacteria heterogeneously activate gene expression programs in response
to environmental changes, stress, and other stimuli. Such behavior may serve as a bet …

In mammalian cells, the decision to proliferate is thought to be irreversibly made at the
restriction point of the cell cycle,, when mitogen signalling engages a positive feedback loop …

Many chemotherapeutic drugs kill only a fraction of cancer cells, limiting their efficacy. We
used live-cell imaging to investigate the role of p53 dynamics in fractional killing of colon …

Gene circuits are dynamical systems that regulate cellular behaviors, often using protein
signals as inputs and outputs. Here we have developed an optogenetic'function …

Microbes transiently differentiate into distinct, specialized cell types to generate functional
diversity and cope with changing environmental conditions. Though alternate programs …

Highlights•Gene expression can be surprisingly dynamic and noisy.•Cell to cell
heterogeneity in gene expression state is a widespread phenomenon.•Phenotypic diversity …

Photo-receptors are widely present in both prokaryotic and eukaryotic cells, which serves as
the foundation of tuning cell behaviors with light. While practices in eukaryotic cells have …

Just like in many engineering systems, impedance-like effects, called retroactivity, arise at
the interconnection of biomolecular circuits, leading to unexpected changes in a circuit's …