Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Myelofibrosis (MF) is a myeloproliferative disorder that exhibits considerable biological and
clinical heterogeneity. At the two ends of the disease spectrum are the myelodepletive or …

CSCs (Cancer stem cells) with distinct metabolic features are considered to cause HCC
(hepatocellular carcinoma) initiation, metastasis and therapeutic resistance. Here, we …

Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and
are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial …

Myeloid malignancies are devastating hematologic cancers with limited therapeutic options.
Inflammation is emerging as a novel driver of myeloid malignancy, with important …

Chronic inflammation with aging (“inflammaging”) plays a prominent role in the
pathogenesis of myeloid malignancies. Aberrant inflammatory activity affects many different …

Somatic loss-of-function mutations of the dioxygenase Ten-eleven translocation-2 (TET2)
occur frequently in individuals with clonal hematopoiesis (CH) and acute myeloid leukemia …

Dysregulation of innate immune signaling pathways is implicated in various hematologic
malignancies. However, these pathways have not been systematically examined in acute …

Cop1 encodes a ubiquitin E3 ligase that has been well preserved during evolution in both
plants and metazoans. In metazoans, the C/EBP family transcription factors are targets for …

The MYC oncogenic transcription factor is acetylated by the p300 and GCN5 histone
acetyltransferases. The significance of MYC acetylation and the functions of specific …