The final common pathway of all routes of complement activation involves the non-
enzymatic assembly of a complex comprising newly formed C5b with the plasma proteins …

Here, we identify iPLA2β as a critical regulator for p53-driven ferroptosis upon reactive
oxygen species (ROS)-induced stress. The calcium-independent phospholipase iPLA2β is …

Enzymes of the phospholipase superfamily are involved in lipid metabolism, as well as
regulation of membrane composition, cell signaling, and inflammation. This review provides …

Idiopathic membranous nephropathy (IMN) is an organ-specific autoimmune disease of the
kidney glomerulus. It may gradually progress to end-stage renal disease (ESRD) …

Various clinical and epidemiologic studies show that nonsteroidal anti-inflammatory drugs
(NSAIDs), including aspirin and cyclooxygenase inhibitors (COXIBs) help prevent cancer …

Complement activation and recruitment of inflammatory leukocytes is an important defense
mechanism against bacterial infection. However, complement also can mediate cellular …

Membranous nephropathy (MN) is an immune complex mediated disease. Although limited
to the kidney, in up to 20% of patients MN is associated with other autoimmune, infectious or …

Calcium-independent phospholipase A 2 γ (iPLA 2 γ)/patatin-like phospholipase domain-
containing lipase 8 (PNPLA8) is one of the iPLA 2 enzymes, which do not require Ca 2+ ion …

Fluvastatin (FLV) is a statin family member that may play a role in modulating a variety of
medical disorders such as atherosclerosis and breast cancer. The present study addresses …

Patatin-like phospholipase domain-containing protein PNPLA8, also termed Ca2+-
independent phospholipase A2γ (iPLA2γ), is addressed to the mitochondrial matrix (or …