Research progress on the mechanism of renal interstitial fibrosis in obstructive nephropathy

K Wang, Q Liao, X Chen - Heliyon, 2023 - cell.com
Renal fibrosis is a common result for various chronic kidney diseases developing to the end
stage. It is a pathological process characterized by the destruction of normal kidney structure …

Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease

V Miguel, IW Shaw, R Kramann - Nature Reviews Nephrology, 2024 - nature.com
Chronic kidney disease (CKD), defined as persistent (> 3 months) kidney functional loss,
has a growing prevalence (> 10% worldwide population) and limited treatment options …

[HTML][HTML] Calponin 2 regulates ketogenesis to mitigate acute kidney injury

Y Gui, Z Palanza, P Gupta, H Li, Y Pan, Y Wang… - JCI insight, 2023 - ncbi.nlm.nih.gov
Abstract Calponin 2 (CNN2) is a prominent actin stabilizer. It regulates fatty acid oxidation
(FAO) by interacting with estrogen receptor 2 (ESR2) to determine kidney fibrosis. However …

SGLT2 inhibition, high-density lipoprotein, and kidney function: a mendelian randomization study

Z Wang, J Wei, W Zhao, R Shi, Y Zhu, X Li… - Lipids in Health and …, 2024 - Springer
Background Sodium-glucose cotransporter 2 (SGLT2) inhibition is recognized for its evident
renoprotective benefits in diabetic renal disease. Recent data suggest that SGLT2 inhibition …

Proteome characterization of liver–kidney comorbidity after microbial sepsis

Y Gui, Y Yu, W Wang, Y Wang, H Lu… - The FASEB …, 2024 - Wiley Online Library
Sepsis is a life‐threatening condition that occurs when the body responds to an infection but
subsequently triggers widespread inflammation and impaired blood flow. These pathologic …

Investigating Relationships Found in the Kidney Microenvironment to Aid in Understanding Malfunctions of Proteins in Chronic Kidney Disease

A Ogunsina - 2023 - digitalcommons.lib.uconn.edu
The kidneys are the filtration organ that helps filter out waste from our body. Kidney disease
is an ailment that causes damage to the kidney so that it cannot filter our blood and other …