The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

Mitotic spindle orientation is essential for cell fate decisions, epithelial maintenance, and
tissue morphogenesis. In most animal cell types, the dynein motor complex is anchored at …

In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

Highlights•The most common interaction is a short, negatively-charged peptide binding
across a groove formed by two to three TPRs.•Longer peptides bind in an extended …

Both cell–cell adhesion and oriented cell division play prominent roles in establishing tissue
architecture, but it is unclear how they might be coordinated. Here, we demonstrate that the …

The nuclear mitotic apparatus (NuMA) protein is well conserved in vertebrates, and
dynamically changes its subcellular localization from the interphase nucleus to the …

Tight and adherens junctions are specialized sites of cell-cell interaction in epithelia and
endothelia, and are involved in barrier, adhesion, and signaling functions. These functions …

Tissue morphogenesis requires the coordinated regulation of cellular behavior, which
includes the orientation of cell division that defines the position of daughter cells in the …

The direction in which a cell divides is determined by the orientation of its mitotic spindle at
metaphase. Spindle orientation is therefore important for a wide range of developmental …

Oriented cell divisions are critical for the formation and maintenance of structured epithelia.
Proper mitotic spindle orientation relies on polarised anchoring of force generators to the …